The Antibiotics In Miscarriage Surgery (AIMS) trial

Not Applicable

Completed

• Conditions: Infection, miscarriage, sepsis, antibiotic prophylaxis; Pregnancy and Childbirth

• Registration Number: ISRCTN97143849
• Lead Sponsor: niversity of Birmingham (UK)

Brief Summary

1. 2018 protocol in: https://www.ncbi.nlm.nih.gov/pubmed/29685179 2. 2019 results in https://www.ncbi.nlm.nih.gov/pubmed/30865795 (added 14/03/2019) 3. 2018 systematic review in https://www.ncbi.nlm.nih.gov/pubmed/29739349 4. 2019 cost-effectiveness analysis in: https://www.ncbi.nlm.nih.gov/pubmed/31402008 (added 14/08/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-17
• Study Completion: 2017-05-16
• Last Update Posted: 9 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 3412

Inclusion Criteria

1. Women with a spontaneous miscarriage (under 22 weeks gestation)
2. Women undergoing surgical evacuation of the uterus (by manual vacuum aspiration, suction curettage or sharp curettage)
3. Willing and able to give informed consent

Exclusion Criteria

1. Induced abortion of pregnancy
2. Septic miscarriage or evidence of infection
3. Allergy to either of the antibiotics
4. Current antibiotic use, or antibiotic use in the 7 days preceding surgical evacuation
5. Current febrile illness (temperature < 38oC)
7. Other contraindication to doxycycline or metronidazole use
8. Patient with condition requiring immediate care e.g. severe haemorrhage
9. Age less than 16 years

Study & Design

• Study Type: Interventional
• Study Design: Not specified