Effect of Vegan Diet on Microbiome and Metabolism

Not Applicable

Not yet recruiting

• Conditions: Vegan Diet

• Registration Number: NCT07003230
• Lead Sponsor: Zhujiang Hospital

Brief Summary

The goal of this interventional study is to investigate how vegan diet affects health in healthy volunteers, Men and women ages 20 - 30 years old. The main questions it aims to answer are:

Change in Microbial community composition and metabolic alterations Changes in plasma metabolic profile. Researchers will compare changes in microbiota and plasma metabolites profile to see the influence of vegan diet in health. In the dietary trial, participants were first assigned to a 2-week omnivorous diet phase, then switched to a 2-week vegetarian diet phase

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-05-08
• Study Start: 2025-05-30
• Study First Submitted QC: 2025-06-03
• Last Update Submitted: 2025-06-03
• Study First Posted: 2025-06-04
• Last Update Posted: 2025-06-04
• Primary Completion: 2025-10-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

healthe Participants, ages 20-30 years old

Exclusion Criteria

1. Oral antibiotic use or acute/chronic inflammation within the past 3 months;
2. Hormone intake within the past 3 months;
3. Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism;
4. Smoking or alcohol consumption;
5. Uncontrolled mental disorders (including a history of psychiatric hospitalization);
6. Currently participating in a weight loss or weight management program;
7. Following a special or medically prescribed diet (e.g., for celiac disease);
8. Comorbid cardiac or renal insufficiency;
9. Chronic constipation;
10. Hypertension;
11. Diabetes mellitus.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Gut microbiota composition in twenty participants	14days，28days	16S rDNA sequencing technology was used to identify the structural and functional changes of intestinal microbiota before and after vegan diet.

Secondary Outcome Measures

Name	Time	Method
Metabolomic profile of twenty participants in serum and feces	14days, 28days	To determine changes of the metabolomic profile in feces and serum after vegan diet

Trial Locations

Locations (1)

Zhujiang hospital; 🇨🇳 Guangzhou, Guangdong, China