The Neural Mechanisms of the Incubation of Cue-induced Craving in Alcohol Dependence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 主要终点
- changes of alcohol craving measured with visual analogue scales
研究概览
简要总结
In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism. Eighty male participants were randomly divided into Four groups, and they were assessed at 7, 14, 30, and 60 days of abstinence for cue-induced alcohol craving . Another group including 19 patients was repeatedly tested for the cue-induced alcohol craving at the above abstinence days. Other psychological and physiological measures were administered at the four abstinence time points.
详细描述
All subjects provided written informed consent after a full explanation of the protocol design.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •met the criteria of DSM-IV for alcohol dependence
- •aged 18-60 years,male
排除标准
- •current or past history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorders
- •with other serious physical diseases (respiratory disorders, cardiovascular disease and so on)
- •other drug abuse except for nicotine
结局指标
主要结局
changes of alcohol craving measured with visual analogue scales
时间窗: abstained from alcohol for 7 days, 14 days, 30 days and 60 days
次要结局
- skin conductance changes in different abstinence days(7, 14, 30 and 60 days after abstained)
- heart rate changes(7, 14, 30 and 60 days after abstained)
- blood pressure changes in different abstinence days(7, 14, 30 and 60 days after abstained)
- changes of Alcohol Urge Questionnaire(7, 14, 30 and 60 days after abstained)