AlcoholPredict: Neuropsychology, Brain Imaging and Genetic Polymorphisms in Binge Drinking
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- CHU de Reims
- Enrollment
- 125
- Locations
- 1
- Primary Endpoint
- Neuropsychological test : Mini International Neuropsychiatric Interview (M.I.N.I)
Study Overview
Brief Summary
The purpose of this study is to specify the psychological, cognitive, neuro-functional and genetic profile associated with binge drinker behaviors among young adults. Results will help identifying more precisely vulnerability factors associated with this pattern of alcohol consumption and guiding prevention efforts.
Detailed Description
Binge drinking behavior is characterised by speed of drinking on a particular occasion, frequency of drunkenness during the most recent six month period, and the percentage of times getting drunk when drinking. The prevalence of weekly binge drinking among European Union drinkers in 2009 was reported to be 28% of the student population, and 33% among all young people aged 15-24. The consequences of this behavior are multiple and often dramatic, they include: academic failure, violent acts, rape, domestic or road accidents. The study aims to identify vulnerability factors associated with binge drinking. The protocol explores the psychological (personality), neuropsychological (executive functions, memory), genetic (snp polymorphisms) and neuro-anatomical (fMRI) patterns associated with binge drinking behavior.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 25 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Males or females
- •Right-handed
- •Aged 18-25 years
- •Native French speaker, able to read French and complete study evaluations
- •Caucasian
- •Able to provide informed written and verbal consent
Exclusion Criteria
- •A significant general medical illness, including neurological disorders, mental retardation or head trauma
- •Depression, bipolar disorder, schizophrenia or schizoaffective disorder diagnostic according to DSM-IV
- •Handling of psychotropics substances
- •A sensorial impairment (visual and/or hearing)
- •Women who are pregnant
- •Contraindication to the use of MRI (pacemaker, metal in their body)
Outcomes
Primary Outcomes
Neuropsychological test : Mini International Neuropsychiatric Interview (M.I.N.I)
Time Frame: day 1
Neuropsychological test : Wisconsin Card Sorting Test (WCST)
Time Frame: V2(3 weeks later)
Genetics tests (Single Nucleotide Polymorphism)
Time Frame: V2(3 weeks later)
MRI - signal BOLD (" Blood Oxygen Level Dependant ").
Time Frame: V3(up to 2 month)
Neuropsychological test : Family Informant Schedule and Criteria (FISC)
Time Frame: day 1
Neuropsychological test : Alcohol Use Questionnaire
Time Frame: day 1
Neuropsychological test :Trail Making Test, partie A et B
Time Frame: V3(up to 2 month)
Neuropsychological test : Plus/Minus Test
Time Frame: V3(up to 2 month)
Neuropsychological test :Go/No-Go
Time Frame: V3(up to 2 month)
Secondary Outcomes
No secondary outcomes reported