Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Hopital Foch
- Locations
- 2
- Primary Endpoint
- Correlation coefficient between patients profile and type of pain
- Status
- Withdrawn
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of the study is to establish the genetic, neurophysiological and psychological phenotype of the patients presenting a persistent neuropathic pain after surgery of the breast cancer, by comparing the neuropathic painful patients with the not painful and with the not neuropathic painful . This will be realized on a transverse cohort ("Seintinelle"cohort) and confirmed on a forward-looking longitudinal cohort.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Women over 18 years
- •Having given a written consent form
- •Affiliated to the social security scheme
- •French language (read, written and spoken)
- •Accepting the principle of the study and able to respect the conditions of the study.
Exclusion Criteria
- •Other cancer or AIDS in evolution
- •Bilateral Mastectomy
- •Presence of chronic pain before the intervention for breast cancer,
- •occupational accident, dispute or search for compensation
- •Previous surgery on the same territory
- •Peripheral neurological pathology or central (brain damage, multiple sclerosis) susceptible to interfere with the evaluation of the post-operative pain
- •Heavy psychiatric histories: psychosis, severe depression having motivated a hospitalization, a suicide attempt
- •Current major depressive episode at the time of the evaluation (cf. criterion diagnosis of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5))
- •Abuse of drug or psychoactive substance (cf. definition of the DSM-5) during the last six months; cognitive disorders (MMSE 24/30) or psychological incompatible with the respect and/or the understanding of the protocol
- •Patients participating in another protocol of biomedical research.
Outcomes
Primary Outcomes
Correlation coefficient between patients profile and type of pain
Time Frame: 13 months max
The genetic profile will be determined from a biological sample of blood taken at the willing patients. This analysis will include: an analysis of candidate genes, an analysis piece-genomics genome-wide association (GWAS) and newer techniques of sequencing of whole exome sequencing allowing to study variants with low and high impact. The psychological profile will be determined by tests estimating the affect, the suffering, the capacities of management of the pain, the emotional regulation and the neuropsychological tests . The neurophysiological profile will be determined by an evaluation quantified by the sensibility, the tests of painful conditioning stimulation, and the analysis of the excitability of nerve fibers.