Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer

Recruitment & Eligibility

Inclusion Criteria

Women over 18 years
Having given a written consent form
Affiliated to the social security scheme
French language (read, written and spoken)
Accepting the principle of the study and able to respect the conditions of the study.

Exclusion Criteria

Other cancer or AIDS in evolution
Bilateral Mastectomy
Presence of chronic pain before the intervention for breast cancer,
occupational accident, dispute or search for compensation
Previous surgery on the same territory
Peripheral neurological pathology or central (brain damage, multiple sclerosis) susceptible to interfere with the evaluation of the post-operative pain
Heavy psychiatric histories: psychosis, severe depression having motivated a hospitalization, a suicide attempt
Current major depressive episode at the time of the evaluation (cf. criterion diagnosis of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5))
Abuse of drug or psychoactive substance (cf. definition of the DSM-5) during the last six months; cognitive disorders (MMSE 24/30) or psychological incompatible with the respect and/or the understanding of the protocol
Patients participating in another protocol of biomedical research.

For longitudinal study:

Inclusion Criteria:

Patients who can be followed during the total duration of the study ( 12 months) for the longitudinal arm of the forward-looking study
Patients that must be operated for one of the two types of surgery: preservative surgery or mastectomy for breast cancer with ganglionic cleaning out
Chemotherapy or radiotherapy before the surgery

Exclusion Criteria:

Previous surgery for a breast cancer
Patients that must be operated for a surgery of the breast without ganglionic cleaning out

For transversal study:

Inclusion criteria:

patients operated for a conservative surgery or a mastectomy for breast cancer with ganglionic cleaning out during 2 years before the inclusion

Exclusion criteria

Study & Design

Arm && Interventions

Group	Intervention	Description
Longitudinal study	Neurophysiological and psychophysical evaluations	Patients that must be operated for a breast cancer
Longitudinal study	Genetical analyses	Patients that must be operated for a breast cancer
Transversal study	Quality of life questionnaires	Patients who had surgery for breast cancer for 2 years or less
Transversal study	Chronic pain identification questionnaires	Patients who had surgery for breast cancer for 2 years or less
Longitudinal study	Chronic pain identification questionnaires	Patients that must be operated for a breast cancer
Transversal study	Neurophysiological and psychophysical evaluations	Patients who had surgery for breast cancer for 2 years or less
Transversal study	Genetical analyses	Patients who had surgery for breast cancer for 2 years or less
Longitudinal study	Quality of life questionnaires	Patients that must be operated for a breast cancer

Primary Outcome Measures

Name	Time	Method
Correlation coefficient between patients profile and type of pain	13 months max	The genetic profile will be determined from a biological sample of blood taken at the willing patients. This analysis will include: an analysis of candidate genes, an analysis piece-genomics genome-wide association (GWAS) and newer techniques of sequencing of whole exome sequencing allowing to study variants with low and high impact. The psychological profile will be determined by tests estimating the affect, the suffering, the capacities of management of the pain, the emotional regulation and the neuropsychological tests . The neurophysiological profile will be determined by an evaluation quantified by the sensibility, the tests of painful conditioning stimulation, and the analysis of the excitability of nerve fibers.

Secondary Outcome Measures

Name	Time	Method

Recruitment & Eligibility