Incubation of Alcohol Craving During Abstinence
Completed
- Conditions
- Alcohol Dependence
- Registration Number
- NCT01991704
- Lead Sponsor
- National Institute on Drug Dependence, China
- Brief Summary
In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism. Eighty male participants were randomly divided into Four groups, and they were assessed at 7, 14, 30, and 60 days of abstinence for cue-induced alcohol craving . Another group including 19 patients was repeatedly tested for the cue-induced alcohol craving at the above abstinence days. Other psychological and physiological measures were administered at the four abstinence time points.
- Detailed Description
All subjects provided written informed consent after a full explanation of the protocol design.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 99
Inclusion Criteria
- met the criteria of DSM-IV for alcohol dependence
- aged 18-60 years,male
Exclusion Criteria
- current or past history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorders
- with other serious physical diseases (respiratory disorders, cardiovascular disease and so on)
- other drug abuse except for nicotine
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method changes of alcohol craving measured with visual analogue scales abstained from alcohol for 7 days, 14 days, 30 days and 60 days
- Secondary Outcome Measures
Name Time Method skin conductance changes in different abstinence days 7, 14, 30 and 60 days after abstained heart rate changes 7, 14, 30 and 60 days after abstained blood pressure changes in different abstinence days 7, 14, 30 and 60 days after abstained changes of Alcohol Urge Questionnaire 7, 14, 30 and 60 days after abstained