Intra-subject variability in pain scoring and the consequences for analgesia treatment

Recruiting

• Conditions: obesitas; Chronic and acute pain; fibromyalgia; obesity; polyneuropathy; 10028302; 10034606

• Registration Number: NL-OMON44114
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

Healthy subjects of either sex between the age of 18 and 75; ;Patient inclusion criteria: (i) Patients diagnosed with fibromyalgia or peripheral polyneuropathy according to the guidelines of the IASP or other professional pain societies (eg., Netherlands Society of Anesthesiologists); or patients scheduled for elective surgery with post-operative opiate treatment; (ii) a pain score of 5 or higher for chronic pain patients; (iii) age between 18 and 75 years;
Obesity patients: BMI > 35

Exclusion Criteria

Medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular
disease; allergy to study medication; use of strong opioids; use of benzodiazepines; raised intracranial pressure;(x) pregnancy and/or lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Heat and electrical pain VAS scores</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Questionnaires for obese patients<br /><br>QST values<br /><br>corneal confocal microscopy results<br /><br>conditioned pain modulation<br /><br>offset analgesia<br /><br>temporal summation</p><br>