The Effect of Long-term Use of Bisphosphonates on Femur Morphology
Overview
- Phase
- Not Applicable
- Intervention
- Bisphosphonates
- Conditions
- Osteoporosis
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Enrollment
- 140
- Locations
- 1
- Primary Endpoint
- femoral lateral bowing
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Recent studies have shown that bone modeling can occur throughout life, suggesting bone has a persistent ability of adapting structure to loading. Some bone medications have a significant effect on the process of bone modeling based on histological studies. Bisphosphonates (BP), a classical anti-resorption drug which impacts the process of bone turnover, is related with atypical femur fractures while the mechanism is unclear. Several hypotheses are considered competitive. Among them, increased femur bowing is associated with atypical femoral fractures. However, it remains doubtful whether long-term BP use increases femur bowing. Thus, the investigators design this retrospective cohort study.
Detailed Description
If the participants meet the Inclusion Criteria, the investigators will collect the baseline characteristics of patients including age, gender, body mass index (BMI), as well as characteristics of BMD by dual-energy X-ray absorptiometry (DXA), BP treatment (type of drugs, duration before baseline). The primary outcome was femoral lateral bowing (FLB), femoral neck shaft angle (FNSA), and hip knee shaft angle (HKSA) from the frontal plane in standing radiographs of the lower limbs.
Investigators
Eligibility Criteria
Inclusion Criteria
- •standing radiographs of the lower limb
Exclusion Criteria
- •non-standard lower limbs X-ray , rheumatoid arthritis, tumor of the femur， congenital anomalies of the lower extremity
Arms & Interventions
patients with over 5-year BP history
patients who took bisphosphonates over 5 years
Intervention: Bisphosphonates
control patients without BP usage
patients who do not receive bisphosphonates therapy
Intervention: Control
Outcomes
Primary Outcomes
femoral lateral bowing
Time Frame: through study completion, an average of 8 years
Angle between axes of 20% proximal and distal sections of femur diaphysis
Secondary Outcomes
- femoral neck shaft angle (FNSA)(through study completion, an average of 8 year)
- hip knee shaft angle(through study completion, an average of 8 years)