Establishment and analysis of a yellow fever vaccination cohort for the identification of individual prognostic factors in vaccinations and acute viral infections

udwig Maximilian University of Munich0 个研究点目标入组 250 人开始时间: 2023年8月26日最近更新: 2023年9月4日

试验速览

•1. Male or female individuals between the ages of 18 and 55 years old
•2. Healthy with no acute infections or chronic diseases
•3. Women must have a negative pregnancy test
•4. Willingness to provide written informed consent after being thoroughly informed of the risks and benefits of the study
•5. Availability for all study time points (i.e., able to attend all study visits)

•1. Pregnant or lactating women
•2. Previously received a yellow fever vaccination
•3. Pre-existing flaviviral diseases such as dengue fever or West e virus infection
•4. Known allergies to egg or egg components or aminoglycosides
•5. A temperature greater than 38°C on the day of study entry or an acute illness (with or without fever) on the same day
•6. Receipt of any other vaccination less than 30 days before the study
•7. A history of autoimmune diseases or immunosuppression
•8. Known anaphylactic or allergic reactions
•9. Using unregistered drugs or drugs in clinical trials
•10. Clinically significant mental illness
•11. Receipt of immunoglobulins or blood products within three months of the study or are planning to do so during the study
•12. Injection drug users
•13. Ongoing tumor diseases
•14. Past or current manifestations of haematological, renal, hepatic, pulmonary, CNS, cardiovascular, or gastrointestinal diseases
•15. Anyone deemed by the investigator to not be compliant with the study objectives and protocol
•16. A foreseeable absence from the study center during the study period, such as due to a planned vacation

发起方

udwig Maximilian University of Munich