Rate Control in Atrial Fibrillation

Phase 4

• Conditions: Atrial Fibrillation
• Interventions: Drug: Carvedilol; Drug: Metoprolol tartrate

• Registration Number: NCT02251509
• Lead Sponsor: Creighton University

Brief Summary

This study will evaluate the efficacy of metoprolol tartrate compared to carvedilol on heart rate control in patients with atrial fibrillation and a rapid ventricular rate.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-09-25
• Study First Submitted QC: 2014-09-25
• Study First Posted: 2014-09-29
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-15
• Last Update Posted: 2016-06-16
• Study Start: 2016-12
• Primary Completion: 2017-09
• Study Completion: 2017-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Permanent atrial fibrillation
• Baseline ventricular rate (prior to treatment) > 110 bpm

Exclusion Criteria

• History of accessory tract re-entry tachycardia
• Ejection fraction < 35% or history of NYHA Class III/IV stage C/D heart failure
• Acute coronary syndrome, percutaneous coronary intervention, or cardiac surgery in the past 2 months
• Child-Pugh class B or C hepatic dysfunction
• Uncontrolled hypertension
• Thyroid disease
• Intolerance to beta-blockers
• History of lung disease resulting in hospitalization in the past year

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Carvedilol	Carvedilol	carvedilol BID for 2 weeks
Metoprolol tartrate	Metoprolol tartrate	Metoprolol tartrate BID for 2 weeks

Primary Outcome Measures

Name	Time	Method
Resting heart rate	2 weeks	Resting heart rate less than 80 bpm

Trial Locations

Locations (1)

Creighton University; 🇺🇸 Omaha, Nebraska, United States