NCT02251509Unknown4 期
Rate Control in Atrial Fibrillation: A Randomized, Double-Blind, Crossover Comparison of Carvedilol and Metoprolol Tartrate
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Resting heart rate
研究概览
简要总结
This study will evaluate the efficacy of metoprolol tartrate compared to carvedilol on heart rate control in patients with atrial fibrillation and a rapid ventricular rate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Permanent atrial fibrillation
- •Baseline ventricular rate (prior to treatment) > 110 bpm
排除标准
- •History of accessory tract re-entry tachycardia
- •Ejection fraction < 35% or history of NYHA Class III/IV stage C/D heart failure
- •Acute coronary syndrome, percutaneous coronary intervention, or cardiac surgery in the past 2 months
- •Child-Pugh class B or C hepatic dysfunction
- •Uncontrolled hypertension
- •Thyroid disease
- •Intolerance to beta-blockers
- •History of lung disease resulting in hospitalization in the past year
研究组 & 干预措施
Carvedilol
Experimental
carvedilol BID for 2 weeks
干预措施: Carvedilol (Drug)
Metoprolol tartrate
Experimental
Metoprolol tartrate BID for 2 weeks
干预措施: Metoprolol tartrate (Drug)
结局指标
主要结局
Resting heart rate
时间窗: 2 weeks
Resting heart rate less than 80 bpm
次要结局
未报告次要终点
研究者
研究点 (1)
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