ight Adaptation in glaucoma- The influence of dynamic light conditions on visual functioning.

Completed

Conditions: Glaucoma
10018307
POAG

Registration Number: NL-OMON45610

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Glaucoma patients between ages 50 and 75, who visit the Ophthalmology clinic at University Medical Center Groningen, that have provided the informed consent form and meet the inclusion-exclusion criteria.
Healthy subjects between ages 50 and 75, who have provided the informed consent form and returned the questionnaire with results which do not indicate ophthalmic abnormalities.

Exclusion Criteria

Glaucoma Patients:
Visual acuity less than 0.8
Non-glaucomatous visual field loss;Healthy Subjects:
Visual acuity less than 0.8
Any visual field loss
Intraocular pressure above 21 mmHg
Positive family history of glaucoma

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Contrast gain control as a function of the frequence in which background<br /><br>luminance changes in time. Contrast sensitivity in central and peripheral sites<br /><br>of the retina will be measured by using a staircase method. The contrast gain<br /><br>control will be defined as the difference between the contrast sensitivity<br /><br>measured at static (0 Hz) versus the dynamic light conditions. The contrast<br /><br>gain control can then be compared between the healthy control group and<br /><br>glaucoma patients. We measure contrast gain control at two different values of<br /><br>the mean background luminance and for two polarities (white (increment) and<br /><br>black (decrement) stimuli on a gray background).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Critical Fusion Frequency (CFF). CFF is the highest frequency at which flicker<br /><br>can be detected. This will be measured in the central and peripheral visual<br /><br>field for a range of background luminances.</p><br>