Intraoperative Posterior Cruciate Ligament (Transcruciate) Injection After Total Knee Arthroplasty (TKA)

Phase 4

Completed

• Conditions: Arthroplasty, Replacement, Knee
• Interventions: Procedure: transcruciate injection of 20cc of normal saline; Procedure: transcruciate injection of 20 cc of 0.5% Ropivacaine

• Registration Number: NCT01345604
• Lead Sponsor: University of Saskatchewan

Brief Summary

his study is being done because total knee replacements can leave patients with considerable pain after surgery. Therefore, many studies have been done to find the best ways to control knee pain after the surgery. Currently, a popular approach is to use many different techniques to control the pain. This includes injecting freezing (local anesthetic) into the spinal column (spinal anesthetic), injecting freezing close to the nerves of the knee and using various kinds of medications (e.g. narcotics and anti-inflammatory medications). Studies have shown using this a combination of techniques can reduce pain and allow earlier discharge from the hospital. However, one downside to this approach is it does not usually control the pain in the back of the knee. One new technique has been used to try and overcome this. This technique is called a "posterior cruciate ligament block" or "PCL block". It involves injecting a drug into the back of the knee which will block the nerves in this area. Sometimes the investigators refer to this as "freezing".

The purpose of our study is to determine whether this "PCL Block" will improve pain after the total knee replacement surgery. The investigators will also determine whether this technique will improve movement in the knee and lessen narcotic usage after the surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-04-28
• Study First Submitted QC: 2011-04-29
• Study Start: 2011-05
• Study First Posted: 2011-05-02
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-10
• Last Update Posted: 2016-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• American Society of Anesthesiologists' (ASA) physical status classification (ASA) I and II patients undergoing unilateral total knee arthroplasty at Saskatoon City Hospital
• Patients recruited from the practice of 4 orthopedic surgeons

Exclusion Criteria

• Inability to obtain informed consent
• Simultaneous bilateral total knee arthroplasty or revision cases
• Preexisting neurological deficits in the distribution of the femoral nerve or known diagnosis of peripheral neuropathy
• Coagulopathies
• Infection either systemically or at the needle insertion sites
• Allergies to local anesthetics or opioids
• Patients with a history of narcotic dependency or chronic pain
• ASA III and IV
• Body Mass Index (BMI) > 40

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	transcruciate injection of 20cc of normal saline	-
Ropivicaine	transcruciate injection of 20 cc of 0.5% Ropivacaine	-

Primary Outcome Measures

Name	Time	Method
Knee flexion	up to one week postoperative

Secondary Outcome Measures

Name	Time	Method
Total narcotic consumption	up to 1 week postoperative
Postoperative pain score	in PACU , on ward (baseline), and post-op day 1 & 2 at 10am & 6pm	Pain scores will be recorded at rest and on attempt of achieving a 90 degree passive flexion of the knee.

Trial Locations

Locations (1)

Saskatoon City Hospital; 🇨🇦 Saskatoon, Saskatchewan, Canada