Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Not Applicable
Completed
- Conditions
- Physiological Changes in Deliberate Apnea
- Interventions
- Device: magnetic resonance imaging (MRI)
- Registration Number
- NCT02280226
- Lead Sponsor
- University Hospital, Bonn
- Brief Summary
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
Inclusion Criteria
- Being able to hold breath deliberately at least 4,5 minutes
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Deliberate Apnea Group magnetic resonance imaging (MRI) Subjects undergo maximum apnea.
- Primary Outcome Measures
Name Time Method Cardiac Function: Duration of Apnea every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements Alteration of cardiac function in subjects undergoing maximum apnea.
Mean Blood Flow Measurement Under Apnea Using MRI Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements Blood flow pattern in subjects undergoing maximum apnea.
- Secondary Outcome Measures
Name Time Method