Evaluating the Influence of Apnea on Heart Function With Strain Analysis and Measurement of Fibrosis Derived From T1-mapping Using Cardiac Magnetic Resonance Imaging (MRI).
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 17
- Primary Endpoint
- Cardiac Function: Duration of Apnea
Study Overview
Brief Summary
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 16 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Being able to hold breath deliberately at least 4,5 minutes
Exclusion Criteria
- Not provided
Arms & Interventions
Deliberate Apnea Group
Subjects undergo maximum apnea.
Intervention: magnetic resonance imaging (MRI) (Device)
Outcomes
Primary Outcomes
Cardiac Function: Duration of Apnea
Time Frame: every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Alteration of cardiac function in subjects undergoing maximum apnea.
Mean Blood Flow Measurement Under Apnea Using MRI
Time Frame: Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Blood flow pattern in subjects undergoing maximum apnea.
Secondary Outcomes
No secondary outcomes reported
Investigators
Jonas Doerner
MD
University Hospital, Bonn