ACTRN12611000657921已完成未知
Week-Week and Month-Month Biological Variation and Reference Change Values of NTproBNP in the Stable Dialysis Population
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •In-centre haemo- or peritoneal dialysis patients established on a single dialysis modality for at least 90-days
- •Stable dialysis prescription for at least one month
- •Aged 18-years or older
- •Able to provide informed consent
- •Echocardiogram within 12-months of enrollment
排除标准
- •Living renal transplantation planned within 5-months of enrolment.
- •Home haemodialysis
- •Patients on peritoneal dialysis not receiving continuous therapy (e.g. NIPD).
- •Permanent pacemaker and/or implantable cardiac defibrillator.
- •Joint replacements, orthopaedic pins, mechanical heart valves and amputations.
- •Any of the following events / conditions in the month prior to screening:
- •Admission to hospital for any cause.
- •Change in dry body weight target of > 1kg.
- •Unscheduled haemodialysis for treatment of hypertension, dyspnoea or congestive cardiac failure.
- •Change in dialysis prescription.
- •Initiation or dose alteration of angiotensin converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, or aldosterone receptor antagonist.
- •If has ischaemic heart disease – change in severity of angina – increased frequency and/or occurrence with lesser degrees of exertion and/or alteration in dose of anti-anginal agent(s).
- •If has arrhythmia – change in dose of anti-arrhythmic agent or initiation of new anti-arrhythmic agent.
- •Systemic infection.
- •Congenital heart disease (excluding haemodynamically insignificant patent foramen ovale).
- •Documented severe left ventricular systolic dysfunction defined as an ejection fraction less than 30% by Simpson’s rule.
- •Severe aortic stenosis or regurgitation.
- •Severe mitral stenosis or regurgitation.
- •Severe pulmonary hypertension (RVSP > [60 mmHg > RA]) due to any cause.
- •ST or non-ST segment myocardial infarction (defined as a combination of serial elevation in Troponin T and any one of new ST/T wave changes on ECG and/or symptoms of cardiac ischaemia) in the 6-months prior to screening.
- •Cardiac surgery and/or coronary angioplasty in the 6-months prior to screening.
- •Pulmonary embolism in the preceding 6-months.
- •Advanced malignancy.
- •Current immunosuppressive pharmacotherapy for any indication.
研究者
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