Fluid responsiveness after cardiac surgery

Withdrawn

• Conditions: Patients admitted to the Intensive Care Unit following Coronary Artery Bypass Grafting (CABG).; Cardiovascular - Coronary heart disease; Surgery - Other surgery

• Registration Number: ACTRN12605000405617
• Lead Sponsor: niversity of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patient booked for CABG surgery.Left ventricular ejection fraction greater than 40% pre-operatively (as determined by echocardiography or radiocontrast ventriculography).Normal cardiac valvular function (defined as mitral or aortic valve regurgitation less than 2+ on echocardiography).Normal respiratory function (defined as absence of documented respiratory pathology or FEV1/FVC greater than or equal to 60%).Absence of oesophageal pathology that would contraindicate transoesophageal echocardiography.

Exclusion Criteria

ECG demonstrates rhythm other than sinus rhythm or AAI pacing post-operatively.Pulmonary hypertension (defined as pulmonary systolic blood pressure greater than 50mmHg as estimated by echocardiography pre-operatively or by pulmonary artery catheter at the time of insertion).Blood loss greater than 250mL in the first hour post-operatively.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
An increase in mean cardiac output, as determined by pulmonary artery catheter thermodilution, by equal to or greater than 10% within half an hour of rapid intravenous fluid administration compared with immediately before fluid administration.[30 minutes]

Secondary Outcome Measures

Name	Time	Method
The impact of varying positive end expiratory pressure (PEEP).[Preload and afterload upon measured variables will be assessed.]