Application of incremental intra-thoracic positive pressure through mechanical ventilation maneuvers: a new tool to predict fluid-responsiveness in patients undergoing pressure support ventilation?

Not Applicable

Completed

• Conditions: Critical illness; Hemodynamic status; Cardiovascular - Other cardiovascular diseases; Fluid responsiveness

• Registration Number: ACTRN12615001232527
• Lead Sponsor: Federico Longhini MD

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-11-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients > 18 years/old undergoing invasive mechanical ventilation in Pressure Support mode (se with a positive end-expiratory pressure between 4 and 6 cmH2O and a Pressure Support betweeen 8 and 12 cmH2O), with a clinical need for fluid infusion, i.e. systolic arterial blood pressure < 90 mmHg or 50 mmHg reduction of values in patients with chronic hypertension, oliguria as defined by a diuresis < 0.5 ml/kg/h, need for inotropes, lactate > 2 mmol/L.

Exclusion Criteria

Patients will be excluded if meeting one or more off the following criteria: 1) cardiac arrhythmia; 2) atrial fibrillation or flutter; 3) patients undergoing any form of renal replacement therapy; 4) valvular defects of moderate to severe grade; 5) history of congestive cardiac failure; 6) previous or presence of pneumothorax or emphysema; 7) patients with Chronic Obstructive Pulmonary Disease (COPD); 8) patients with kyphoscoliosis; 9) use of expiratory muscles and 10) arterial partial pressure to inspired fraction of oxygen (PaO2/FiO2) ratio < 200.

Study & Design

• Study Type: Interventional
• Study Design: Not specified