Predicting fluid responsiveness by reverse tidal volume challenge in patients undergoing high-risk surgery
Phase 1
- Conditions
- Patients older than 18 yr who schedule for high-risk surgery with mechanically ventilated during general anesthesiahigh-risk surgery during general anesthesia, surgery with mechanically ventilated during general anesthesia, reverse tidal volume challenge, fluid responsiveness, pulse pressure variation
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1. Adult (age equal to or more than 19 years) patient
2. High-risk surgical procedure (expected operative time more than 2 hours and need an invasive arterial pressure monitoring)
Exclusion Criteria
1. patients with preoperative cardiac arrhythmia, moderate to severe valvular heart disease, preoperative left ventricular ejection fraction <40%, right ventricular dysfunction, intracardiac shunts
2. moderate to severe chronic obstructive pulmonary disease, acute lung injury, coexisting open thorax condition
3. moderate to severe renal or liver disease
4. preoperative need of inotropes and vasopressor
5. severe bradycardia
6. abdominal compartment syndrome
7. pregnancy
8. spontaneous breathing
9. Decline to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AUROC of PPV change after reverse tidal volume challenge to predict fluid responsiveness within 10-15minute (after fluid challenge) Absolute change of PPV after reverse tidal volume challenge
- Secondary Outcome Measures
Name Time Method sensitivity and specificity of PPV change after reverse tidal volume challenge to predict fluid responsiveness within 10-15minute (after fluid challenge) Absolute change of PPV after reverse tidal volume challenge