High-density Activation Mapping of the Slow Pathwayto Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia

Not Applicable

Completed

• Conditions: Atrioventricular Nodal Re Entrant Tachycardia; Supraventricular Tachycardia
• Interventions: Device: Description of Slow pathway signals to facilitate ablation

• Registration Number: NCT05531903
• Lead Sponsor: Parc de Salut Mar

Brief Summary

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia inducible during an electrophysiological study. Although ablative therapy proved to be the treatment of choice, little is known about the components of the tachycardia circuit. The aim of this study is to detect the presence and patterns of specific electrograms representing slow pathway (SP) potentials and to explore Koch's triangle pattern activation during sinus rhythm and/or atrial extraestimulus with a high-density mapping catheter in an attempt to clarify a fast and safety catheter ablation strategy. We hypothesized that, in patients with dual atrioventricular nodal physiology, during sinus rhythm (SR), high-density mapping (HDM) catheters could identify the SP signals, making possible to delineate small areas of slow conduction associated to abnormal electrograms on Koch's triangle. On a second step, radiofrequency (RF) applications safety guided by the HDM obtained with this method, should interrupt the circuit far from the His region. Finally, SP signals should disappear after the RF procedure when performing a new 3D HDM. A control group of patients without AVN dual physiology should show absence of fragmented/slow conduction zones.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-08-28
• Study First Submitted QC: 2022-09-07
• Study First Posted: 2022-09-08
• Study Start: 2022-10-15
• Primary Completion: 2023-07-30
• Study Completion: 2023-09-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-10
• Last Update Posted: 2024-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 119

Inclusion Criteria

• Patients > 18 yo with AVNRT observed after electrophysiological study

Exclusion Criteria

• Patients < 18 yo

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with atrioventricular node reentrant tachycardia	Description of Slow pathway signals to facilitate ablation	Patient with documented AVNRT and fragmented/slow conduction zones observed in a 3D high density mapping

Primary Outcome Measures

Name	Time	Method
Absence of reinduction of AVNRT after abolition of fragmented/slow conduction signals	one day	Number of patients with absence of fragmented/slow conduction signals observed during sinus rhythm or atrial pacing after radiofrequency application

Secondary Outcome Measures

Name	Time	Method
Absence of AVNRT relapses	one month	Number of patients with absence of relapses after 1 month of the electrophysiological study
Percentage of patient without AVNRT reinduction after procedure	One day	Percentage of patients without tachycardia induction after radiofrequency applications protocol

Trial Locations

Locations (1)

Jesús Ignacio Jiménez López; 🇪🇸 Barcelona, Spain