The effect of an anise-based product in Iranian traditional medicine, on the Treatment of patients with chronic rhinosinusitis (CRSsNP) , in comparison to fluticasone nasal sprayMedicine
- Conditions
- Chronic sinusitis, unspecified.Sinusitis (chronic) NOS
- Registration Number
- IRCT2014010516083N1
- Lead Sponsor
- Deputy of Research,Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 74
patients with presence of chronic rhinosinusitis symptoms for at least 12 weeks; positive CT result indicating the opacity and swelling of the sinus; Patients 18 to 75 years of both sexes; Treatment with systemic or nasal antibiotics or corticosteroids within 4 weeks before visit; Treatment wit h oral corticosteroids within the 30 days before visit; Treatment with topical corticosteroids within 15 days before visit.
Exclusion criteria: nasal and sinus surgery within the last 5 years; Presence of moderate to severe co-morbid asthma and mild asthma having exacerbation within 30 days prior to trial inclusion; Rhinitis medicamentosa (drug induced rhinitis); Known hypersensitivity to the medication or excipients; The signs and symptoms of bacterial sinusitis (fever = 38.5, ocular complications, severe unilateral frontal headache or toothache); Acute seasonal allergy; other diseases which in the opinion of the investigator disqualifies the patient for trial enrolment(such as heart failure, kidney, lung and liver, drug addiction or alcoholism, neurological or psychiatric diseases, cancer, immunodeficiency) in the past 5 years; any side effect during treatment; Pregnancy; Breastfeeding
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recovery. Timepoint: before intervention (day 0), and end of intervention (day 28). Method of measurement: SNOT-22 Questionnaire.
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: day 7; day 28. Method of measurement: Ask the patient; The patient stated.