Role of MRI Diffusion in Differentiation Between Benign and Malignant Bony Lesions

• Conditions: Efficacy of MRI Diffusion in Differentiation Between Benign and Malignant Bony Lesions
• Interventions: Device: MRI

• Registration Number: NCT03463291
• Lead Sponsor: Assiut University

Brief Summary

Bone tumors are categorized according to their tissue of origin into cartilagenous, osteogenic, fibrogenic, fibrohistiocytic, haematopoietic, vascular, and lipogenic tumors.

Magnetic resonance imaging (MRI) is now indispensable for the preoperative workup and therapeutic follow-up of patients with musculoskeletal tumors.

The application of DW-MRI in bone marrow is today an established examination technique that provides a unique contrast and that can help in the detection of bone-marrow pathologies and the differentiation of benign and malignant bone-marrow lesions.

Diffusion MRI provides quantitative and qualitative assessments of tissue cellularity and cell-membrane integrity. It is widely used for tumour detection, characterisation, and monitoring during treatment. Diffusion MRI supplies functional information that complements the structural evaluation.

In combination with standard structural MRI parameters, the ADC value improves tumour characterization. Diffusion MRI can also be used to monitor tumours during chemotherapy. Tumour necrosis results in loss of cell membrane integrity and in expansion of the extracellular compartment, leading to greater water-molecule diffusion with an increase in the ADC value.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-03
• Study First Submitted: 2018-03-06
• Study First Submitted QC: 2018-03-10
• Last Update Submitted: 2018-03-10
• Study First Posted: 2018-03-13
• Last Update Posted: 2018-03-13
• Study Start: 2018-05
• Primary Completion: 2020-05
• Study Completion: 2020-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All patients with bony lesions will be included in the study.

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Exclusion Criteria

• Patient with cardiac pacemaker.
• Patients with metallic prosthesis in the region of examination.
• Patients with claustrophobia.
• Patient with recent history of surgical or imagining guided biopsy from the bony lesion.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	MRI	All patients with bony lesions

Primary Outcome Measures

Name	Time	Method
The ADC value of MRI diffusion in benign and malignant bony lesions ( considering ADC value <1.2 ..malignant while ADC>1.2 ..benign)	1 day