De invloed van Gaviscon op de acid pocket en zure reflux.
Recruiting
- Conditions
- GERDGastro-esophageal reflux diseaseGORZgastro-oesofageale reflux ziekte
- Registration Number
- NL-OMON25536
- Lead Sponsor
- Prof. dr. G.E. BoeckxstaensAcademic Medical Center
- Brief Summary
Previous publications on this subject from our group: <br><br> Beaumont H, Bennink RJ, de Jong J et al. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. Gut 2010;59(4):441-51. <br><br> Rohof WO, Bennink RJ, Hirsch DP et al. Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period. Gut. 2012 Jan 20. [Epub ahead of print].
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. GERD confirmed by pH-impedance (ph<4 in > 4,5 % of time or positive symptom association), or in patients with reflux esophagitis;
2. Written informed consent;
Exclusion Criteria
1. Surgery of the gastrointestinal tract other than appendectomy;
2. Inability to stop the use of proton pump inhibitors for one week;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome is the number of acid reflux episodes detected on pH-impedance measurements.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are postprandial esophageal acid exposure, the rate of acid versus non acid reflux events, the number of non acid reflux events and the position of the acid pocket, relative to the crural diaphragm.