Clonidine Versus Midazolam for Premedication
Not Applicable
Completed
- Conditions
- AnxietyPain
- Interventions
- Registration Number
- NCT00638729
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Brief Summary
alpha2-agonists like clonidine offer several useful effects that make these drugs an interesting alternative to benzodiazepines for pharmacological premedication. We therefore sought to determine the effect of pre-anesthetic medication with clonidine vs. midazolam in a randomized, double-blind, placebo controlled study. Effects of pre-anesthetic medication were assessed on (1) bispectral index (BIS),(2) sedation score and visual analog scales for anxiety and pain, (3) neuropsychologic tests to assess cognitive function and (4) circulating stress hormones.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- elective surgery
- ASA physical status I and II
- informed consent
- weight 50 - 100 kg
Exclusion Criteria
- cardiovascular disease
- pregnancy
- problems of consent due to mentally handicap or language.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo placebo Pre-anesthetic medication with an inert tablet, p.o., 60-90 min prior to estimated induction time Midazolam midazolam Pre-anesthetic medication with midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time Clonidine clonidine pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
- Primary Outcome Measures
Name Time Method Effect of premedication on bispectral index prior study medication until 2 h postoperatively
- Secondary Outcome Measures
Name Time Method Effect of premedication on postoperative recovery prior to study medication until 2 h postoperatively
Trial Locations
- Locations (1)
Department of Anaesthesiology and Intensive Care Medicine, University of Schleswig-Holstein Campus Kiel
🇩🇪Kiel, Germany