The Efficiency of Conditioned Pain Modulation is Associated With Levels of Pain Catastrophizing in Patients With Chronic Low Back Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Association between levels of pain catastrophizing thoughts and endogenous pain inhibition
研究概览
简要总结
This study evaluates the potential association between pain catastrophizing thoughts and the ability to dampen pain via endogenous descending inhibition. Half of the participants are persons with chronic low back pain and the other half are age and gender-matched controls
详细描述
Pain catastrophizing is a cognitive feature commonly seen in various musculoskeletal pain population and is considered an important factor to account for in rehabilitation. The ability to dampen pain via endogenous pain modulatory mechanisms is likewise known to be reduced in musculoskeletal pain conditions.
Studies utilizing functional magnetic resonance imaging (fMRI) have demonstrated that the supraspinal areas involved in pain-related cognitive processing to a great extent overlap with those involved in endogenous pain modulation. Therefore, it is plausible that factors such as pain catastrophizing thoughts may affect the nervous systems ability to dampen pain.
Chronic low back pain is the single clinical problem with the biggest impact in the modern society. Previous studies have demonstrated that pain catastrophizing and reduced endogenous pain inhibition are part of the clinical picture. However, previous studies have never investigated a potential relationship between these two factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
盲法说明
The participants are blind to the study hypothesis and therefore the expected outcome of the tests performed
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Low back pain group:
- •chronic low back pain ( lasting more than 3 months)
- •intensity of ≥ 3/10 on a numeric rating scale
- •pain is located in the area between the gluteal folds below to the thoracolumbal junction above.
- •No current or previous history of musculoskeletal pain of ongoing nature
排除标准
- •Applies for both groups:
- •Signs of radicular pain or other specific medical conditions e.g. rheumatologic disease or diabetes
- •Pregnancy
结局指标
主要结局
Association between levels of pain catastrophizing thoughts and endogenous pain inhibition
时间窗: One session (45 min)
The pain catastrophizing scale score is correlated with the changes in Pressure Pain Thresholds before and after the cold pressor test See descriptions of each assessment method below (outcome 2 and outcome 3, respectively)
次要结局
- Changes in pressure pain thresholds (determined with pressure algometry) before and after the cold pressor test(30 minutes)
- Catastrophizing thoughts measured with the Pain Catastrophizing Scale(15 minutes)
研究者
Thorvaldur Skuli Palsson
Principal Investigator
Aalborg University