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Clinical Trials/NCT05730166
NCT05730166CompletedNot Applicable

Conditioned Pain Modulation Induced by Mechanical Stimulation. A Mechanism of Manual Therapy Analgesia: Study 2

Josue Fernandez Carnero2 sites in 1 country24 target enrollmentStarted: February 15, 2023Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
24
Locations
2
Primary Endpoint
Change from Baseline in Tibialis Anterior Pressure Pain Threshold (PPT) to immediate post-conditioning stimulus

Study Overview

Brief Summary

The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius at moderate intensity compared to mild intensity or non-painful.

Detailed Description

The mechanical stimulus produced in manual therapy (MT) techniques elicits neurophysiological responses within the peripheral and central nervous system responsible for pain inhibition. Almost all types of MT elicit a neurophysiological response that is associated with the descending pain modulation circuit. But it has not been demonstrated whether this inhibition occurs through a conditioned pain modulation mechanism induced by painful mechanical stimulation that is carried out with manual therapy techniques.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Treatment
Masking
Single (Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 65 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • healthy male or female between 18 and 65 years
  • Free of pain and with no history of chronic pain

Exclusion Criteria

  • Pregnant or having given birth within the last year

Outcomes

Primary Outcomes

Change from Baseline in Tibialis Anterior Pressure Pain Threshold (PPT) to immediate post-conditioning stimulus

Time Frame: At baseline and immediately after the conditioning stimulus

PPTs will be assessed on the dominant side over the tibialis anterior muscle using a digital algometer (Wagner instruments, Greenwich, CT, USA). Participants will be instructed to say "stop" when the pressure sensation becomes painful.The average of 3 assessments on the tibialis anterior of the dominant side will be performed for analysis. The algometer pressure for assessment will be gradually increased at a rate of 1kg/second. Data will be collected in kg/cm2.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Josue Fernandez Carnero
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Josue Fernandez Carnero

Professor

Universidad Rey Juan Carlos

Study Sites (2)

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