Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?

Completed

• Conditions: Habituation

• Registration Number: NCT03237650
• Lead Sponsor: Ruhr University of Bochum

Brief Summary

Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM). However, it is unknown whether the pain relief results from habituation to the repeated painful electric stimulation. We compared the effects of CPM and habituation on PCES-induced pain and PCES-evoked potentials and analyzed whether increased attention by a random change of electric intensities amplifies the habituation effects.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Status Verified: 2017-07
• Study First Submitted: 2017-07-30
• Study First Submitted QC: 2017-07-30
• Last Update Submitted: 2017-07-30
• Study First Posted: 2017-08-02
• Last Update Posted: 2017-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• healthy volunteers

Exclusion Criteria

• any kind of disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pain relief	during the measurement	pain intensity of painful cutaneous electrical stimulation on a numeric rating scale (NRS 0-100)
N1P1-amplitude	during the measurement	Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV

Secondary Outcome Measures

Name	Time	Method
N1-latency	during the measurement	Latency of the peak N1 of painful cutaneous electrical stimulation evoked potentials in msec
P0N1-amplitude	during the measurement	Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV