NL-OMON47623已完成不适用
Effect of Intravenous Administration of C1-inhibitor on Inflammation and Coagulation after Bronchial Instillation of House Dust Mite Allergen and Lipopolysaccharide in Allergic Asthma Patients - CAST-study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •- Mild asthma patients between 18 and 45 years
- •- Allergy for house dust mite
- •- Spirometry FEV1 more than 70% of predicted value
- •- A PC20 between 1.2 * 9.6 mg/ml
- •- Stable asthma without the use of asthma medication 2 weeks prior to the study day
- •- No current smoking for at least 1 year and less than 10 pack years of smoking history
- •- No clinically significant findings during physical examination and hematological and biochemical screening
- •- Normal defecation pattern (defined as *3x/ day and *3x/week)
排除标准
- •- Relevant comorbidity, pregnancy and/or recent surgical procedures.
- •- A history of smoking within the last 12 months, or regular consumption of greater than three units of alcohol per day
- •- Exacerbation and/ or the use of asthma medication within 2 weeks before start
- •- Administration of any investigational drug within 30 days of study initiation
- •- Donation of blood within 60 days, or loss of greater than 400 ml of blood within 12 weeks of study initiation
- •- Inability to maintain stable without the use of asthma medication 2 weeks before start.
- •- History of venous or arterial thromboembolic disease
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