Comparison of Acceleromyography and Mechanomyography for Establishing Potency of Neuromuscular Blocking Agents, A Randomized Controlled Study

Rigshospitalet, Denmark1 site in 1 country40 target enrollmentDecember 2007

ConditionsNeuromuscular Blockade

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Neuromuscular Blockade
Sponsor: Rigshospitalet, Denmark
Enrollment: 40
Locations: 1
Primary Endpoint: Comparison of ED50 with the two methods
Status: Completed
Last Updated: 18 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using rocuronium as an example. We hypothesized that there would be no significant difference between potencies estimated using acceleromyography and mechanomyography.

Registry

clinicaltrials.gov

Start Date

December 2007

End Date

February 2008

Last Updated

18 years ago

Study Type

Interventional

Sex

All

Investigators

Sponsor

Rigshospitalet, Denmark

Eligibility Criteria

Inclusion Criteria

•ASA I-III
•Ideal weight +/-20%
•Both arms available for neuromuscular monitoring
•Surgery in supine position
•Participated surgery time more than 30 min

Exclusion Criteria

•Pregnant and breast-feeding women
•Patients with known illness or use of medications known to influence the neuromuscular transmission
•Known significant renal or hepatic dysfunction
•Allergy to medications used in the study