The Effects of High Dose Fish Oil Supplementation on Delayed Onset Muscle Soreness and Inflammatory Markers

Phase 2

Completed

Conditions: Muscle Damage
Muscle Inflammation

Interventions: Drug: Lovaza (omega-3-acid ethyl esters)
Drug: Wheat Germ Oil

Registration Number: NCT00805870

Lead Sponsor: Western Michigan University

Brief Summary: The purpose of this study is to determine the effects of fish oil supplementation (Lovaza, GlaxoSmithKline) on muscle strength, muscle soreness and inflammation following exercise.

Detailed Description: When a person exercises at a high intensity or starts a new exercise program, muscle soreness will develop. Muscle soreness that peaks between 24-72 hours after exercise and diminishes in 5-7 days is characterized as delayed onset muscle soreness (DOMS). DOMS is associated with the eccentric phase of exercise, where the muscle is actively creating force while lengthening. The onset of muscle soreness is part of an inflammatory response due to the muscular damage caused by the exercise.

Research has shown that fish oils have anti-inflammatory properties. Direct intake of various polyunsaturated fatty acids (PUFA) alters the cell membrane fatty acid composition, which, in turn modulates cell/tissue response to infection, injury and inflammatory events. These properties may be beneficial to relieve muscle soreness.

Therefore, the purpose of this study is to determine the effects of fish oil supplementation (Lovaza, GlaxoSmithKline, 3 grams per day for 65 days) on muscle strength, muscle soreness and inflammation following exercise.

Participants will be randomly assigned to one of two groups: Lovaza (3 grams/day) or placebo. Participants will consume either the Lovaza or the placebo for 65 consecutive days. On Day 60, participants will have baseline measurements of muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory marker assessed. Participants will then perform eccentric exercise on an isokinetic dynamometer using the quadriceps muscles in order to induce muscle soreness. On each of Days 61-65, muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory markers will again be assessed.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 20

Inclusion Criteria

Healthy, free of disease
Must be able to swallow capsules
Free of orthopedic or muscular injuries
Recreationally active
Prior consumption of fish and corn with no adverse reactions

Exclusion Criteria

Use of non-steroidal anti-inflammatory drugs (NSAIDS) or topical analgesics during study enrollment
Pregnant or nursing
Food allergy to fish or any components of the pills which includes alpha tocopherol, partially hydrogenated vegetable oils including soybean oils and gelatin and glycerol or wheat germ oil
Competitive athlete or physically active more than 10 hours per week

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Fish Oil	Lovaza (omega-3-acid ethyl esters)	Lovaza, 3 grams/day for 65 days
Control	Wheat Germ Oil	Wheat Germ Oil, 3 grams/day for 65 days

Primary Outcome Measures

Name	Time	Method
Quadriceps Muscle Strength	6 days	Quadriceps muscle strength is the maximal amount of force that the quadriceps muscles can produce during isometric knee extension exercise.
Muscle Soreness of the Quadriceps Using an Algometer Strain Gauge	6 days	The required amount of force applied to the quadriceps to elicit pain or discomfort.
Creatine Kinase Activity Measured in Blood	6 days	Creatine kinase activity is an indirect indicator of muscle damage.
Interleukin-6 Measured in Blood	6 days	Interleukin-6 is an indirect indicator of muscle inflammation.