The Effects of High Dose Fish Oil Supplementation on Delayed Onset Muscle Soreness and Inflammatory Markers
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Quadriceps Muscle Strength
研究概览
简要总结
The purpose of this study is to determine the effects of fish oil supplementation (Lovaza, GlaxoSmithKline) on muscle strength, muscle soreness and inflammation following exercise.
详细描述
When a person exercises at a high intensity or starts a new exercise program, muscle soreness will develop. Muscle soreness that peaks between 24-72 hours after exercise and diminishes in 5-7 days is characterized as delayed onset muscle soreness (DOMS). DOMS is associated with the eccentric phase of exercise, where the muscle is actively creating force while lengthening. The onset of muscle soreness is part of an inflammatory response due to the muscular damage caused by the exercise.
Research has shown that fish oils have anti-inflammatory properties. Direct intake of various polyunsaturated fatty acids (PUFA) alters the cell membrane fatty acid composition, which, in turn modulates cell/tissue response to infection, injury and inflammatory events. These properties may be beneficial to relieve muscle soreness.
Therefore, the purpose of this study is to determine the effects of fish oil supplementation (Lovaza, GlaxoSmithKline, 3 grams per day for 65 days) on muscle strength, muscle soreness and inflammation following exercise.
Participants will be randomly assigned to one of two groups: Lovaza (3 grams/day) or placebo. Participants will consume either the Lovaza or the placebo for 65 consecutive days. On Day 60, participants will have baseline measurements of muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory marker assessed. Participants will then perform eccentric exercise on an isokinetic dynamometer using the quadriceps muscles in order to induce muscle soreness. On each of Days 61-65, muscle strength, muscle soreness, creatine kinase activity, and muscle inflammatory markers will again be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, free of disease
- •Must be able to swallow capsules
- •Free of orthopedic or muscular injuries
- •Recreationally active
- •Prior consumption of fish and corn with no adverse reactions
排除标准
- •Use of non-steroidal anti-inflammatory drugs (NSAIDS) or topical analgesics during study enrollment
- •Pregnant or nursing
- •Food allergy to fish or any components of the pills which includes alpha tocopherol, partially hydrogenated vegetable oils including soybean oils and gelatin and glycerol or wheat germ oil
- •Competitive athlete or physically active more than 10 hours per week
研究组 & 干预措施
Fish Oil
Lovaza, 3 grams/day for 65 days
干预措施: Lovaza (omega-3-acid ethyl esters) (Drug)
Control
Wheat Germ Oil, 3 grams/day for 65 days
干预措施: Wheat Germ Oil (Drug)
结局指标
主要结局
Quadriceps Muscle Strength
时间窗: 6 days
Quadriceps muscle strength is the maximal amount of force that the quadriceps muscles can produce during isometric knee extension exercise.
Muscle Soreness of the Quadriceps Using an Algometer Strain Gauge
时间窗: 6 days
The required amount of force applied to the quadriceps to elicit pain or discomfort.
Creatine Kinase Activity Measured in Blood
时间窗: 6 days
Creatine kinase activity is an indirect indicator of muscle damage.
Interleukin-6 Measured in Blood
时间窗: 6 days
Interleukin-6 is an indirect indicator of muscle inflammation.
次要结局
未报告次要终点
研究者
Christopher Cheatham
Chair and Associate Professor
Western Michigan University