The Role of Pelvic Microbiomes During the Malignant Transformation of Benign Ovarian Diseases
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Difference of species distribution of microorganism according to 16s RNA analysis
研究概览
简要总结
This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture. Discharges/flushing fluid from vagina, faces and fimbria end of fallopian tube are collected from age and menopausal status matched patient before and during procedures of laparoscopies. The discharges/flushing fluid would be sent for 16s RNA analysis and microculture respectively, and the results would get self-contrasted comparison and case-control comparison.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Laparoscopy procedures
- •Specific pathological diagnosis
排除标准
- •Previous history of pelvic surgeries
- •Evidences of pelvic inflammation diseases
结局指标
主要结局
Difference of species distribution of microorganism according to 16s RNA analysis
时间窗: 2 years
The difference of species of microorganism distribution according to 16s RNA sequencing analysis between control group and study group, and between different sampling sites in each arm
Difference of species distribution of microorganism according to microculture outcomes
时间窗: 2 years
Difference of species distribution of microorganism according to microculture outcomes between control group and study group, and between different sampling sites in each arm
次要结局
未报告次要终点
研究者
Lei Li
Professor
Peking Union Medical College Hospital