Analysis of Biological Progression and Regression of HELLP Syndrome in Time

Recruiting

• Conditions: HELLP Syndrome; Preeclampsia

• Registration Number: NCT06758960
• Lead Sponsor: CHU Mohammed VI Marrakech

Brief Summary

Prospective observational study about progression and regression of biological parameters of HELLP syndrome

Detailed Description

Data collection included a comprehensive review of pathological histories, identification of complications based on clinical presentation, daily monitoring of biological parameters, documentation of transfusion events, recording of corticosteroid administration according to gestational age, and detailed reporting of extraction and analgesia techniques.

Study Timeline

• Study Start: 2023-07-01
• Status Verified: 2024-12
• Study First Submitted: 2024-12-15
• Study First Submitted QC: 2024-12-28
• Last Update Submitted: 2024-12-28
• Study First Posted: 2025-01-06
• Last Update Posted: 2025-01-06
• Primary Completion: 2025-07-31
• Study Completion: 2025-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• Pregnant women who are admitted to the maternal ICU for a biological HELLP syndrome

Exclusion Criteria

• Patients whose biological presentation was attributable to other conditions, such as microangiopathies or leukemia.
• Patients who benefited from plasma exchange therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelets count	Up to 10 days	Platelets count will be monitored daily before and after delivery

Secondary Outcome Measures

Name	Time	Method
Concentration of Lactate dehydrogenase	Up to 10 days	Monitored daily before and after delivery
Concentration of Liver enzymes	Up to 10 days	daily monitoring of alkaline phosphatase, alanine transaminase before and after delivery

Trial Locations

Locations (1)

CHU Mohammed VI of Marrakech; 🇲🇦 Marrakech, Marrakech - Safi, Morocco