Elucidation of refractoriness in treating systemic lupus erythematosus - Research for refractory SLE

Kyoto University0 个研究点目标入组 40 人开始时间: 2020年10月31日最近更新: 2023年10月17日

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•Exclusion criteria common among studies corresponding to selection criteria 1-4 are patient's refusal to the consent and patients under 15 years of age. In addition, the following exclusion criteria is established. 1. Standard treatment refractory patient exclusion criteria: When the attending physician deems it inappropriate due to complications (eg, malignant tumor, renal disorder with eGFR <15, severe lung disorder, central nervous system disorder). 2. Exclusion criteria for patient's refractory to specific drug treatment: Excludes patients with central nervous system disorders and highly active nephritis. When the attending physician considers it inappropriate due to other complications (for example, malignant tumor, serious lung disorder). 3. Exclusion criteria for cases of difficulty in reducing steroid dose due to fatigue: When the attending physician deems it inappropriate due to taking medication for the patient, because of complications (eg, malignant tumor, renal disorder with eGFR <15, severe lung disorder, central nervous system disorder, hypothyroidism) and neuropsychiatric symptoms that can cause fatigue 4. Exclusion criteria for healthy subjects: When the attending physician deems it inappropriate due to complications (for example, complications of malignant tumors, autoimmune diseases, eGFR <15, serious lung disorders, central nervous system disorders).

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