Dipeptide Alanyl Glutamine and Postoperative Insulin Resistance in Colon Carcinoma Patients
Recruiting
- Conditions
- Insulin resistanceTemporary diabetes100184241001799110017998
- Registration Number
- NL-OMON35623
- Lead Sponsor
- Medisch Centrum Alkmaar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- Age between 18 and 75 year
- Colon cancer patients scheduled for elective open abdominal surgery
- Capable of giving informed consent
Exclusion Criteria
- Patients who are participating in another clinical trial
- Unable to receive oral intake
- Major malabsorption disorder of the gut
- Patients with diabetes mellitus
- Use of certain medication: thyroid medication, corticosteroids, diuretic medication
- BMI above 30 kg/m2
- Known bleeding disorders or increased PTT and/or APTT
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our primary objective is to reduce/prevent the postoperative insulin resistance<br /><br>in colon cancer patients by the intravenous or enteral and perioperative<br /><br>administration of the dipeptide alanyl-glutamine.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- The effect of the dipeptide alanyl-glutamine on intracellular signalling in<br /><br>muscle tissue.<br /><br>- The effect of the dipeptide alanyl-glutamine on glutathione concentration in<br /><br>muscle tissue.<br /><br>- The effect of the dipeptide alanyl-glutamine on the amino acid concentration<br /><br>in muscle tissue.<br /><br>- The effect of the dipeptide alanyl-glutamine on the inflammatory response in<br /><br>the circulating compartment.<br /><br>- The effect of the dipeptide alanyl-glutamine on antioxidant/oxidant<br /><br>parameters in the circulating compartment.<br /><br>- The effect of the dipeptide alanyl-glutamine on the inflammatory response in<br /><br>liver tissue.<br /><br>- The effect of the dipeptide alanyl-glutamine on the<br /><br>inflammatory response in fat tissue.<br /><br></p><br>