Cerebrovascular Autoregulation During and After Liver Transplantation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Changes of cerebrovascular autoregulation during liver transplantation
研究概览
简要总结
The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.
详细描述
The cerebrovascular autoregulation (AR) will be measured using transcranial doppler and calculating the index of autoregulation Mx. This measurement is continuous with online calculation. So, the possible changes over the whole time of surgery can be detected. Furthermore, the measurement of AR at the ICU will be performed daily at the same time over a measurement period of 60 Minutes and the time course of AR after liver transplantation will be described.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver transplantation
- •age > 18 years
排除标准
- •preexisting cerebral diseases
- •traumatic brain injury
- •pregnancy
结局指标
主要结局
Changes of cerebrovascular autoregulation during liver transplantation
时间窗: During the surgery
Measuring cerebrovascular autoregulation during the whole liver transplantation and compare the index of AR at the beginning with index of AR Mx after reperfusion of the transplantated liver
次要结局
- Time course of cerebrovascular autoregulation after liver transplantation(First 4 days after transplantation)
研究者
Patrick Schramm
Principal investigator
Johannes Gutenberg University Mainz