Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

Withdrawn

• Conditions: Septic Shock; Severe Sepsis

• Registration Number: NCT01926301
• Lead Sponsor: Johannes Gutenberg University Mainz

Brief Summary

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.

Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2013-08-17
• Study First Submitted QC: 2013-08-17
• Study First Posted: 2013-08-20
• Status Verified: 2020-06
• Primary Completion: 2020-06
• Study Completion: 2020-06
• Last Update Submitted: 2020-06-09
• Last Update Posted: 2020-06-11

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• severe sepsis or septic shock
• adult patients
• possibility of transcranial Doppler ultrasound

Exclusion Criteria

• traumatic brain injury
• known cerebrovascular diseases
• Infection of the brain
• chronic renal failure
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebrovascular autoregulation	during the first 4 days	Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock

Secondary Outcome Measures

Name	Time	Method
Delirium	at day 4	Incidence of Delirium at day 4 after severe sepsis or septic shock

Trial Locations

Locations (1)

University Medical Center of the Johannes Gutenberg-Univerity; 🇩🇪 Mainz, Germany