Cerebrospinal Fluid IL-6, IL-8 and PCT as Early Marker of an Intrathecal Infection in Neurosurgical Patients

Completed

• Conditions: External Ventricular Drainage Associated Infection; Intrathecal Infection

• Registration Number: NCT02875808
• Lead Sponsor: University Medicine Greifswald

Brief Summary

The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.

Detailed Description

The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.

Study Timeline

• Study Start: 2014-08-01
• Study First Submitted: 2016-08-18
• Study First Submitted QC: 2016-08-22
• Study First Posted: 2016-08-23
• Primary Completion: 2016-09-01
• Study Completion: 2017-12-12
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-05
• Last Update Posted: 2018-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• external ventricular drainage
• informed consent

Exclusion Criteria

• no informed consent
• prior intrathecal infection
• prior systemic infection / sepsis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
increasing IL-6, IL-8 and PCT prior to an clinically apparent intrathecal infection/ a detection with the goldstandard	08/ 2014 - 12/ 2016

Trial Locations

Locations (1)

Department of Neurosurgery; 🇩🇪 Greifswald, Germany