Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications in the Context of Total Hip Arthroplasty
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Jena
- Enrollment
- 512
- Locations
- 1
- Primary Endpoint
- Presence of heterotopic ossification (HO)
Overview
Brief Summary
Aim of this study is to proof the efficacy of in Jena established prophylaxis of new bone formation aside the skeleton with irradiation and compare it with the common literature. Furthermore we want to compare irradiation treatment with the alternative prophylaxis with analgetics from the NSAID type.
Detailed Description
Aim of this retrospective analysis is to compare the incidence of heterotopic ossification one year after total hip arthroplasty with the at our location established concept of irradiation 24h preoperative and incidence in common literature. Furthermore the comparison between irradiated patients and patients treated with NSAIDs.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with total hip arthroplasty performed at Eisenberg Patients with preoperative irradiation (24h pre-op) or postoperative diclofenac treatment Patients with x-ray images immediately (3-5 days postoperative) postoperative and at least 365 days postoperative
Exclusion Criteria
- •Patients with missing follow up image
Arms & Interventions
Intervention group with prophylactic irradiation
Patients with total hip arthroplasty and irradiation (preoperative on the day before the operation (>24h preoperative)) Quantity: 128 Period: 01.01.2013 - 31.12.2023
Intervention: Radiation (Radiation)
Control group with prophylactic NSAID-treatment
Patients with total hip arthroplasty and diclofenac treatment Quantity: 384 Period: 01.01.2013 - 31.12.2023
Intervention: Diclofenac (Drug)
Outcomes
Primary Outcomes
Presence of heterotopic ossification (HO)
Time Frame: at least 365 days postoperative
X-ray controlled HO diagnostics with the Brooker classification
Secondary Outcomes
No secondary outcomes reported
Investigators
Matthias Mäurer
Principal Investigator
University of Jena