The effect of oral Channa striatus extract versus Glucosamine sulphate on Knee Osteoarthritis patients

Phase 2

Completed

• Conditions: knee osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12615000901505
• Lead Sponsor: niversiti Sains Malaysia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-08-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

1-All patients with unilateral or bilateral knee osteoarthritis according to clinical and radiological criteria of the American College of Rheumatology (ACR) (Altman et al. 1986)
Knee pain and radiographic osteophytes plus at least one of three symptoms/signs listed below:
-age more than 40 years OR
-stiffness less than 30 minutes OR
-crepitus.
This criteria is widely accepted as the standard diagnosis criteria for knee OA with 91% sensitivity and 86% specificity.

2-Have a radiological grade between I and III, as measured with the Kellgren-Lawrence method of Classification.
3-Patients have symptoms for at least three months.

Exclusion Criteria

1-Patient with secondary knee osteoarthritis, such as post traumatic OA, inflammatory arthritis, specifically rheumatoid arthritis, active gout
2-Disabling co-morbid condition such as renal disease, liver disease, neoplasm, and other rheumatic diseases.
3-Pregnancy or nursing.
4-Patient with severe knee pain and willing for surgical intervention.
5-Those who had joint lavage, arthroscopy, or treatment with hyaluronic acid during the previous 6 months.
6-Patient who had been treated with intra-articular corticosteroids during the past 3 months.
7-Patient who have allergic to oral C.striatus or Glucosamine

Study & Design

• Study Type: Interventional
• Study Design: Not specified