A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
- Conditions
- Relapsed/Refractory Follicular LymphomaMarginal Zone Lymphoma
- Interventions
- Registration Number
- NCT05100862
- Lead Sponsor
- BeiGene
- Brief Summary
The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 780
- Histologically confirmed grade 1-3a FL or MZL
- Previously treated with ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
- Need for systemic therapy for FL or MZL
- Measurable disease by computed tomography or magnetic resonance imaging
- Adequate bone marrow, liver and renal function
Key
- Transformation to aggressive lymphoma
- Requiring ongoing need for corticosteroid treatment
- Clinically significant cardiovascular disease
- Prior malignancy within the past 2 years
- Active fungal, bacterial, and/or viral infection that requires systemic therapy
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Follicular Lymphoma Arm A: Zanubrutinib plus Obinutuzumab Zanubrutinib Participants will receive zanubrutinib and Obinutuzumab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first. Follicular Lymphoma Arm A: Zanubrutinib plus Obinutuzumab Obinutuzumab Participants will receive zanubrutinib and Obinutuzumab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first. Follicular Lymphoma Arm B: Lenalidomide plus Rituximab Rituximab Participants will receive lenalidomide and rituximab. Marginal Zone Lymphoma Arm C: Zanubrutinib plus Rituximab Zanubrutinib Participants will receive zanubrutinib and rituximab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first. Follicular Lymphoma Arm B: Lenalidomide plus Rituximab Lenalidomide Participants will receive lenalidomide and rituximab. Marginal Zone Lymphoma Arm C: Zanubrutinib plus Rituximab Rituximab Participants will receive zanubrutinib and rituximab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first. Marginal Zone Lymphoma Arm D: Lenalidomide plus Rituximab Rituximab Participants will receive lenalidomide and rituximab. Marginal Zone Lymphoma Arm D: Lenalidomide plus Rituximab Lenalidomide Participants will receive lenalidomide and rituximab.
- Primary Outcome Measures
Name Time Method Progression-free Survival As Determined By A Blinded Independent Review Committee (BIRC) Approximately 78 months
- Secondary Outcome Measures
Name Time Method Time to Next Ant-Lymphoma Treatment Approximately 87 months Overall Survival Approximately 87 months Progression-free Survival As Determined By Investigator Assessment Approximately 87 months Overall Response Rate As Determined By BIRC And By Investigator Assessment Approximately 87 months Complete Response Rate As Determined By BIRC And By Investigator Assessment Approximately 87 months Time To Response As Determined By BIRC And By Investigator Assessment Approximately 87 months Health-related Quality Of Life (HRQoL) Using EORTC QLQ-C30) Approximately 87 months HRQ0L assessed by The European Organization For Research On Treatment Of Cancer Quality Of Life Questionnaire-core 30 (EORTC QLQ-C30) consists of 30 questions that are associated with 5 functional scales (physical, role, cognitive, emotional, and social), 3 symptom scales (fatigue, pain, and nausea and vomiting), and 6 single symptom items ( dyspnoea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). The scores range from 0 to 100 and higher score indicates better quality of life.
Duration Of Response As Determined By BIRC And By Investigator Assessment Approximately 87 months HRQoL Using European Quality of Life 5 Dimension 5 Level Questionnaire [EQ 5D 5L) Approximately 87 months The EQ-5D-5L is comprised of a descriptive module and a visual analogue scale. The EQ-5D-5L descriptive module comprises the following 5 dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems, and extreme problems. The visual analogue scale records the respondent's self-rated health on a 0 to 100 scale, with 100 labeled "the best health you can imagine" and 0 labeled "the worst health you can imagine. Higher scores indicate better quality of life.
HRQoL Using National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Symptom Index-18 [FLymSI 18) Approximately 87 months The FLymSI-18 is comprised of 18 questions which cover 4 sub-scales: physical symptoms, emotional symptoms, side effects, and functional well-being. Scores are based on the 5-level Likert scale with 5 possible responses ranging from 0 'Not at all' to 4 'Very much' and is divided into a total score. Higher score indicates better quality of life.
Number of Participants Experiencing Adverse Events (AEs) From first dose to 28 days after the last dose of zanubrutinib or lenalidomide, 90 days after the last dose of obinutuzumab or rituximab, or until the date of confirmed disease progression, whichever comes later (Approximately 87 months)
Trial Locations
- Locations (291)
Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
Ondokuz Mayis University Medicine Faculty Hospital
🇹🇷Atakum Samsun, Turkey
Dokuz Eylul University
🇹🇷Balcova, Turkey
Bagcilar Medipol Mega Hospital
🇹🇷Istanbul, Turkey
Kocaeli Universitesi Tip Fakultesi
🇹🇷Kocaeli, Turkey
Vkv American Hospital
🇹🇷Tevikiye, Turkey
Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
The Christie Hospital
🇬🇧Greater Manchester, United Kingdom
Huddersfield Royal Infirmary
🇬🇧Huddersfield, United Kingdom
Nhs Highland
🇬🇧Inverness, United Kingdom
Hopital Larchet Chu Nice
🇫🇷Nice, France
Reseau Hospitalier Neuchatelois
🇨🇭La ChauxdeFonds, Switzerland
Ucsf Fresno University of California San Francisco Fresno
🇺🇸Fresno, California, United States
Kaiser Permanente Southern California
🇺🇸Irvine, California, United States
Cancer and Blood Specialty Clinic
🇺🇸Los Alamitos, California, United States
Los Angeles Cancer Network
🇺🇸Los Angeles, California, United States
Valkyrie Clinical Trials
🇺🇸Los Angeles, California, United States
UCLA Hematologyoncology
🇺🇸Los Angeles, California, United States
Scripps Health
🇺🇸San Diego, California, United States
Sharp Healthcare Sharp Memorial Hospital
🇺🇸San Diego, California, United States
Baptist Md Anderson Cancer Center
🇺🇸Jacksonville, Florida, United States
Memorial Cancer Institute, Memorial Healthcare System
🇺🇸Pembroke Pines, Florida, United States
Ascension Sacred Heart
🇺🇸Pensacola, Florida, United States
Northwest Georgia Oncology Centers Marietta
🇺🇸Marietta, Georgia, United States
Cancer Care Specialists of Illinois
🇺🇸Decatur, Illinois, United States
Fort Wayne Medical Oncology and Hematology
🇺🇸Fort Wayne, Indiana, United States
Mission Cancer and Blood
🇺🇸Waukee, Iowa, United States
Cotton Oneil Cancer Center
🇺🇸Topeka, Kansas, United States
Cancer Center of Kansas
🇺🇸Wichita, Kansas, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
Christus Highland Cancer Treatment Center
🇺🇸Shreveport, Louisiana, United States
Luminis Health Anne Arundel Medical Center
🇺🇸Annapolis, Maryland, United States
University of Maryland Greenebaum Comprehensive Cancer Center
🇺🇸Baltimore, Maryland, United States
Ascension St Agnes Hospital
🇺🇸Baltimore, Maryland, United States
American Oncology Partners of Maryland Pa
🇺🇸Bethesda, Maryland, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Corewell Health the Michigan Cancer Consortium
🇺🇸Grand Rapids, Michigan, United States
Ascension St John Hospital
🇺🇸Grosse Pointe Woods, Michigan, United States
Hattiesburg Hematology and Oncology Clinic
🇺🇸Hattiesburg, Mississippi, United States
University of Missouri Hospital, Ellis Fischel Cancer Center
🇺🇸Columbia, Missouri, United States
Oncology Hematology Associates
🇺🇸Springfield, Missouri, United States
St Vincent Frontier Cancer Center
🇺🇸Billings, Montana, United States
Nebraska Cancer Specialists (Satellite Site)
🇺🇸Omaha, Nebraska, United States
Nebraska Cancer Specialists
🇺🇸Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
Iyengar Hematology Oncology Medical Center Pa
🇺🇸Bayonne, New Jersey, United States
North Shore Hematology Oncology Associates Eccc Bronx
🇺🇸Bronx, New York, United States
New York Cancer and Blood Specialists
🇺🇸East Setauket, New York, United States
North Shore Hematology Oncology Associates New Hyde Park
🇺🇸New Hyde Park, New York, United States
Chu Montpellier Hopital Saint Eloi
🇫🇷Montpellier, France
North Shore Hematology Oncology Associates Dba New York Cancer and Blood Specialists (New York)
🇺🇸New York, New York, United States
Suny Upstate Medical University
🇺🇸Syracuse, New York, United States
Clinical Research Alliance, Inc
🇺🇸Westbury, New York, United States
Levine Cancer Institute Wake Forest
🇺🇸Charlotte, North Carolina, United States
Oncology Hematology Care Clinical Trials, Llc
🇺🇸Cincinnati, Ohio, United States
Mainline Health Lankenau Institute For Medical Research
🇺🇸Wynnewood, Pennsylvania, United States
Cancer Care Associates of York
🇺🇸York, Pennsylvania, United States
Prairie Lakes Healthcare System
🇺🇸Watertown, South Dakota, United States
Texas Oncology Baylorcharles A Sammons Cancer Center
🇺🇸Dallas, Texas, United States
Harris Health Lyndon B Johnson Hospital
🇺🇸Houston, Texas, United States
Md Anderson Cancer Center
🇺🇸Houston, Texas, United States
Texas Oncology Longview Cancer Center
🇺🇸Longview, Texas, United States
Texas Oncology Palestine Cancer Center
🇺🇸Palestine, Texas, United States
Texas Oncology Paris
🇺🇸Paris, Texas, United States
Northeast Texas Cancer and Research Institute
🇺🇸Tyler, Texas, United States
Northwest Medical Specialties
🇺🇸Puyallup, Washington, United States
University of Washington
🇺🇸Seattle, Washington, United States
Medical Oncology Associates
🇺🇸Spokane, Washington, United States
Hospital Aleman
🇦🇷Caba, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Gosford Hospital
🇦🇺Gosford, New South Wales, Australia
St George Hospital
🇦🇺Kogarah, New South Wales, Australia
Orange Health Hospital
🇦🇺Orange, New South Wales, Australia
Port Macquarie Base Hospital
🇦🇺Port Macquarie, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Sunshine Coast Hospital and Health Service
🇦🇺Birtinya, Queensland, Australia
Townsville University Hospital
🇦🇺Douglas, Queensland, Australia
Genesiscare North Adelaide
🇦🇺North Adelaide, South Australia, Australia
Monash Health
🇦🇺Clayton, Victoria, Australia
Epworth Freemasons
🇦🇺East Melbourne, Victoria, Australia
St Vincents Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Cabrini Hospital Malvern
🇦🇺Malvern East, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal Perth Hospital
🇦🇺Perth, Western Australia, Australia
Perth Blood Institute
🇦🇺West Perth, Western Australia, Australia
La Trobe Regional Hospital
🇦🇺Melbourne, Australia
Medizinische Universitatsklinik Innsbruck
🇦🇹Innsbruck, Austria
Uk St Poelten
🇦🇹St Polten, Austria
Medical Univeristy Vienna
🇦🇹Wien, Austria
Hanusch Krankenhaus
🇦🇹Wien, Austria
Wiener Gesundheitsverbund Klinik Ottakring
🇦🇹Wien, Austria
Institut Jules Bordet
🇧🇪Anderlecht, Belgium
Az Sint Jan Brugge
🇧🇪Brugge, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gand, Belgium
University Hospitals Leuven
🇧🇪Leuven, Belgium
Hospital de Amor Barretos
🇧🇷Barretos, Brazil
Clinica de Oncologia Reichow
🇧🇷Blumenau, Brazil
Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu
🇧🇷Botucatu, Brazil
Instituto Dor de Pesquisa E Ensino Distrito Federal
🇧🇷Brasilia, Brazil
Universidade de Campinas Centro de Hematologia E Hemoterapia
🇧🇷Campinas, Brazil
Fundacao Universidade de Caxias Do Sul
🇧🇷Caxias do Sul, Brazil
Centro Integrado de Oncologia de Curitiba Ss Cionc
🇧🇷Curitiba, Brazil
Hospital Erasto Gaertner
🇧🇷Curitiba, Brazil
Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)
🇧🇷Florianopolis, Brazil
Complexo Hospitalar de Niteroi
🇧🇷Niteroi, Brazil
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
🇧🇷Porto Alegre, Brazil
Instituto Dor de Pesquisa E Ensino Pernambuco
🇧🇷Recife, Brazil
Instituto Dor de Pesquisa E Ensino
🇧🇷Recife, Brazil
Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
🇧🇷Ribeirao Preto, Brazil
Instituto Americas Ensino, Pesquisa E Inovacao
🇧🇷Rio de Janeiro, Brazil
Hospital Sao Rafaelinstituto Dor de Pesquisa E Ensino
🇧🇷Salvador, Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica
🇧🇷Salvador, Brazil
Hospital Nove de Julho Dasa
🇧🇷Sao Paulo, Brazil
Instituto Dor de Pesquisa E Ensino Sao Paulo
🇧🇷Sao Paulo, Brazil
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
🇧🇷Sao Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
🇧🇷Sao Paulo, Brazil
Hospital Santa Rita de Cassia Afecc
🇧🇷Vitoria, Brazil
Umhat Svgeorgi Ead
🇧🇬Plovdiv, Bulgaria
Acibadem City Clinic Tokuda Umhat Ead, Department of Medical Oncology
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital For Active Treatment Saint Ivan Rilski
🇧🇬Sofia, Bulgaria
NHATHD
🇧🇬Sofia, Bulgaria
British Columbia Cancer Agency the Vancouver Centre
🇨🇦Vancouver, British Columbia, Canada
Newfoundland and Labrador Health Services
🇨🇦St Johns, Newfoundland and Labrador, Canada
Queen Elizabeth Ii Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada
Juravinski Cancer Centre
🇨🇦Hamilton, Ontario, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Ciusss Du Saguenay Lac St Jean
🇨🇦Chicoutimi, Quebec, Canada
Centre Integre de Sante Et de Services Sociaux de Chaudiere Appalaches
🇨🇦Levis, Quebec, Canada
Ciusss de Lest de Lile de Montreal Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
Unite de Recherche Clinique Du Cisss Des Laurentides
🇨🇦SaintJerome, Quebec, Canada
Ciusss de Lestrie Chus
🇨🇦Sherbrooke, Quebec, Canada
Oncology Research Center Ltd
🇬🇪Tbilisi, Georgia
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
🇨🇦Quebec, Canada
The First Affiliated Hospital of Wannan Medical College
🇨🇳Wuhu, Anhui, China
Beijing Friendship Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Beijing Cancer Hospital
🇨🇳Beijing, Beijing, China
Beijing Friendship Hospital, Capital Medical University(Tongzhou)
🇨🇳Beijing, Beijing, China
Chongqing Cancer Hospital
🇨🇳Chongqing, Chongqing, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
The First Peoples Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Sun Yat Sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Huizhou Central Peoples Hospital
🇨🇳Huizhou, Guangdong, China
Meizhou People Hospital
🇨🇳Meizhou, Guangdong, China
Affiliated Hospital of Guangdong Medical University
🇨🇳Zhanjiang, Guangdong, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Anyang Tumor Hospital
🇨🇳Anyang, Henan, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
The First Peoples Hospital of Changde City
🇨🇳Changde, Hunan, China
Jiangsu Province Hospital
🇨🇳Nanjing, Jiangsu, China
Affiliated Hospital of Nantong University
🇨🇳Nantong, Jiangsu, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Wuxi Peoples Hospital
🇨🇳Wuxi, Jiangsu, China
K Eristavi National Center of Experimental and Clinical Surgery Jsc
🇬🇪Tbilisi, Georgia
The First Affiliated Hospital of Nanchang University Branch Donghu
🇨🇳Nanchang, Jiangxi, China
Jiangxi Province Cancer Hospital
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University Branch Xianghu
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Liaoning Cancer Hospital and Institute
🇨🇳Shenyang, Liaoning, China
Peoples Hospital of Rizhao
🇨🇳Rizhao, Shandong, China
The Second Affiliated Hospital of Shandong First Medical University
🇨🇳Taian, Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Shanxi Provincial Cancer Hospital
🇨🇳Taiyuan, Shanxi, China
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China
Dongyang Peoples Hospital
🇨🇳Dongyang, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
The First Hospital of Jiaxing
🇨🇳Jiaxing, Zhejiang, China
Jinhua Municipal Central Hospital
🇨🇳Jinhua, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Fakultni Nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Fakultni Nemocnice Olomouc
🇨🇿Olomouc, Czechia
Hopital Prive Dantony, Departement Dhemathologie
🇫🇷Antony, France
Centre Hospitalier Le Mans
🇫🇷Le Mans, France
Institut Curie
🇫🇷Paris, France
Necker University Hospital
🇫🇷Paris, France
Icans Institut de Cancerologie Strasbourg Europe
🇫🇷Strasbourg, France
Chu Nancy Hopital Brabois
🇫🇷VandoeuvrelesNancy, France
High Technology Hospital Medcenter Ltd
🇬🇪Batumi, Georgia
JSC VIAN
🇬🇪Kutaisi, Georgia
University Hospital of Alexandroupolis
🇬🇷Alexandroupolis, Greece
Evaggelismos
🇬🇷Athens, Greece
General Hospital of Athens Alexandra
🇬🇷Athens, Greece
University Hospital of Patra
🇬🇷Patras, Greece
St Jamess Hospital
🇮🇪Dublin, Ireland
University Hospital Waterford
🇮🇪Waterford, Ireland
Haemek Medical Center
🇮🇱Afula, Israel
Assuta Ashdod Medical Center
🇮🇱Ashdod, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah En Karem Medical Center
🇮🇱Jerusalem, Israel
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Chaim Sheba Medical Center
🇮🇱Ramat gan, Israel
Assuta Medical Center
🇮🇱Tel Aviv Jaffa, Israel
Sourasky Tel Aviv Medical Center
🇮🇱Tel Aviv Jaffa, Israel
Cro Irccs Aviano
🇮🇹Aviano, Italy
Irccs Azienda Ospedaliero Universitaria Bologna
🇮🇹Bologna, Italy
Aou Careggi, Servizio Sanitario Toscana
🇮🇹Firenze, Italy
Istituto Europeo Di Oncologia
🇮🇹Milano, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
🇮🇹Milano, Italy
Aou Maggiore Della Carita
🇮🇹Novara, Italy
Azienda Ospedaliera Di Padova
🇮🇹Padova, Italy
Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi
🇮🇹Pavia, Italy
Arcispedale S Maria Nuova Ausl Reggio Emilia Hematology Unit
🇮🇹Reggio Emilia, Italy
Aou Santa Maria Della Misericordia Di Udine
🇮🇹Udine, Italy
Ospedale Di Circolo E Fondazione Macchi
🇮🇹Varese, Italy
Aichi Cancer Center Hospital Clinical Oncology
🇯🇵Nagoya, Aichi, Japan
Chiba Cancer Center
🇯🇵Chibashi, Chiba, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa, Chiba, Japan
Matsuyama Red Cross Hospital
🇯🇵Matsuyamashi, Ehime, Japan
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
🇯🇵Hiroshimashi, Hiroshima, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵SapporoShi, Hokkaido, Japan
Aiiku Hospital
🇯🇵SapporoShi, Hokkaido, Japan
Kanagawa Cancer Center
🇯🇵Yokohamashi, Kanagawa, Japan
University Hospital, Kyoto Prefectural Univ of Medicine
🇯🇵KyotoShi, Kyoto, Japan
Tohoku University Hospital
🇯🇵Sendaishi, Miyagi, Japan
Kurashiki Central Hospital
🇯🇵Kurashikishi, Okayama, Japan
Kansai Medical University Hospital
🇯🇵Hirakata, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama, Osaka, Japan
Tokyo Metropolitan Komagome Hospital
🇯🇵Bunkyoku, Tokyo, Japan
National Cancer Center Hospital
🇯🇵ChuoKu, Tokyo, Japan
Cancer Institute Hospital of Jfcr
🇯🇵Kotoku, Tokyo, Japan
Yamagata University Hospital
🇯🇵Yamagatashi, Yamagata, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
National Hospital Organization Okayama Medical Center
🇯🇵Okayama, Japan
Yokohama Municipal Citizens Hospital
🇯🇵YokohamaShi, Japan
Inje University Busan Paik Hospital
🇰🇷BusanjinGu, Busan Gwang'yeogsi, Korea, Republic of
Dong A University Hospital
🇰🇷SeoGu, Busan Gwang'yeogsi, Korea, Republic of
Pusan National University Hospital
🇰🇷SeoGu, Busan Gwang'yeogsi, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷BundangGu SeongnamSi, Gyeonggi-do, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷BukGu, Gyeongsangbukdo, Korea, Republic of
Gyeongsang National University Hospital
🇰🇷JinjuSi, Gyeongsangnamdo, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷HwasunGun, Jeollanam-do, Korea, Republic of
Samsung Medical Center
🇰🇷GangnamGu, Seoul Teugbyeolsi, Korea, Republic of
The Catholic University of Korea, Seoul St Marys Hospital
🇰🇷SeochoGu, Seoul Teugbyeolsi, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷SeodaemunGu, Seoul Teugbyeolsi, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center
🇰🇷SongpaGu, Seoul Teugbyeolsi, Korea, Republic of
Soon Chun Hyang University Hospital Seoul
🇰🇷YongsanGu, Seoul Teugbyeolsi, Korea, Republic of
Szpital Uniwersytecki Nr Im Dr Jana Biziela
🇵🇱Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne Klinika Hematologii I Transplantologii
🇵🇱Gdask, Poland
Pratia Onkologia Katowice
🇵🇱Katowice, Poland
Pratia McM Krakow
🇵🇱Krakow, Poland
Uniwersytecki Szpital Kliniczny W Poznaniu, Oddzial Hematologii I Transplantacji Szpiku
🇵🇱Poznan, Poland
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
🇵🇱Torun, Poland
Centralny Szpital Kliniczny Uck Wum
🇵🇱Warszawa, Poland
Instytut Hematologii I Transfuzjologii
🇵🇱Warszawa, Poland
Narodowy Instytut Onkologii Im Marii Skodowskiej Curie Hematology Unit
🇵🇱Warszawa, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil, Epe
🇵🇹Porto, Portugal
Unidade Local de Saude Gaia E Espinho
🇵🇹VILA NOVA DE GAIA Porto, Portugal
Auxilio Mutuo Cancer Center
🇵🇷San Juan, Puerto Rico
Coltea Clinical Hospital
🇷🇴Bucharest, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
🇷🇴ClujNapoca, Romania
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
Spitalul Clinic Judetean de Urgenta Bihor
🇷🇴Oradea, Romania
University of Cape Town
🇿🇦Cape Town, South Africa
Haemalife
🇿🇦Kuils River, South Africa
Alberts Cellular Therapy
🇿🇦Pretoria, South Africa
Ico Badalona
🇪🇸Badalona, Spain
Hospital Universitario de Burgos
🇪🇸Burgos, Spain
Hospital Universitario Puerta Del Mar
🇪🇸Cadiz, Spain
Hospital Universitario Virgen de Las Nieves
🇪🇸Granada, Spain
Institut Catala Doncologia Hospital Duran I Reynals
🇪🇸Hospitalet de LLobregat, Spain
Complejo Asistencial Universitario de Leon
🇪🇸Leon, Spain
Hospital de La Princesa
🇪🇸Madrid, Spain
Clinica Universidad de Navarra
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario Ramon Y Cajal
🇪🇸Madrid, Spain
H Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Hospital Clinico Universitario Virgen de La Arrixaca
🇪🇸Murcia, Spain
Clinica Universidad de Navarra Pamplona
🇪🇸Pamplona, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcon, Spain
Hospital Universitario de Salamanca
🇪🇸Salamanca, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
Hospital Universitari Mutua Terrassa
🇪🇸Terrassa, Spain
St Claraspital
🇨🇭Basel, Switzerland
Hfr Fribourg
🇨🇭Fribourg, Switzerland
Universitatsspital Zurich
🇨🇭Zurich, Switzerland
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
🇹🇷Ankara, Turkey
Ankara University Medical Faculty
🇹🇷Ankara, Turkey
Gazi University Medical School
🇹🇷AOCiftlii, Turkey
The Leeds Teaching Hospitals Nhs Trust
🇬🇧Leeds, United Kingdom
Barts Health Nhs Trust
🇬🇧London, United Kingdom
University College Hospital
🇬🇧London, United Kingdom
Derriford Hospital
🇬🇧Plymouth, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom