Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

Not yet recruiting

• Conditions: Clinical Outcome
• Interventions: Diagnostic Test: prognostic nutritional index calculated from laboratory parameters

• Registration Number: NCT05373836
• Lead Sponsor: Seoul National University Hospital

Brief Summary

There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

Detailed Description

In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.

Study Timeline

• Study First Submitted: 2022-04-24
• Study First Submitted QC: 2022-05-09
• Study First Posted: 2022-05-13
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-17
• Last Update Posted: 2024-04-19
• Study Start: 2024-12-12
• Primary Completion: 2025-12-01
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

Exclusion Criteria

• Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
• Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
brain tumor surgery	prognostic nutritional index calculated from laboratory parameters	adult patients undergoing brain tumor surgery

Primary Outcome Measures

Name	Time	Method
predictability of prognostic nutritional index for mortality after brain tumor surgery	From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years	Odds ratio of prognostic nutritional index for postoperative mortality

Secondary Outcome Measures

Name	Time	Method
predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery	From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years	Odds ratio of prognostic nutritional index for postoperative renal replacement therapy
relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery	From date of surgery until the date of hospital discharge	Odds ratio of prognostic nutritional index for length of hospital stay
predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery	From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years	Odds ratio of prognostic nutritional index for postoperative acute kidney injury