An epidemiologic study on the effects of HIV-infection on oxidative stress and of moderate endurance training (marathon) on immune function - The 42 KM Cologne Project

• Conditions: B23.8; HIV disease resulting in other specified conditions

• Registration Number: DRKS00011592
• Lead Sponsor: niversitätsklinikum BonnMedizinische Klinik I

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2010-08-07
• Study Start: 2017-02-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

HIV-infection
- certificate of the treating HIV-specialist that participation in marathon and lactacte stress test is possible
- signed informed consent form before inclusion

Exclusion Criteria

- younger than 18 years
- missing health certificate
- obvious reason not to participate in Marathon running
- new AIDS-defining event = 1 months before inclusion
- malignant disease with current chemotherapy
- organ transplant
- Treatment with systemic corticosteroids = 3 months before inclusion

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CD4 cell count, viral load 12, 9, and 6 months and right before the marathon run. Number and severity of infections during the whole observation period and 4 weeks afterwards.

Secondary Outcome Measures

Name	Time	Method
Metabolic Parameters (lipids, glucose), safety Parameters (liver transaminases, creatinkinase, Phosphate), immunologic Parameters (CD4T-cell apoptosis), oxidative stress and antioxidative capacity (with photometric analysis of capillary blood); quality of life with Medical Outcomes Study HIV Health Survey (MOS-HIV) 12, 9, and 6 months and right before the marathon run