A study to compare the effect of two forms of pain relieving drug -morphine( immediate release morphine and controlled release morphine) in advanced cancer patients.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Advanced stage cancer patients who are suffering due to pain
- Registration Number
- CTRI/2017/09/009817
- Lead Sponsor
- JIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
All cancer patients enrolled in JIPMER Palliative Clinic at Regional Cancer Centre (RCC), whose pain is controlled with morphine 60 mg/day and higher dose.
Exclusion Criteria
1.Patients < 18 years of age.
2.Elderly patients who are bedridden.
3.Patients who are hearing impaired, visually impaired & aphasic.
4.Patients who are on other pain medications with morphine.
5.Patients who require other treatments like irradiation, nerve blocks, epidural anesthesia etc., for their pain management along with morphine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Pain intensity measured using visual analog scale and Brief pain inventory questionnaire at 3weeks <br/ ><br>2. Plasma morphine and its metabolites concentration using Liquid chromatography - Mass Spectrometry <br/ ><br>Timepoint: One and half years <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Side effects developed during the treatment <br/ ><br>2.Total dose of morphine required for each formulation. <br/ ><br>3.Total cost of each phase of treatment per patient. <br/ ><br>4.No. of rescue doses of morphine required. <br/ ><br> <br/ ><br>Timepoint: One and half years