A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
- Conditions
- Idiopathic Pulmonary FibrosisProgressive Pulmonary Fibrosis
- Interventions
- Registration Number
- NCT06238622
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
This study is open to people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). They can only take part if they have completed treatment in a previous study with a medicine called nerandomilast or BI 1015550 (study 1305-0014 or 1305-0023).
The goal of this study is to find out how well people with pulmonary fibrosis tolerate long- term treatment with nerandomilast. The study also tests whether nerandomilast improves lung function and prolongs the time until symptoms get worse, participants need to go to the hospital, or die.
Every participant takes nerandomilast as tablets for up to 1 year and 10 months. The participants may also continue their regular treatment for pulmonary fibrosis during the study.
Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. Participants also regularly do lung function tests.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1700
- Patients who completed treatment in the parent trials (1305-0014 or 1305-0023) without prematurely discontinuing treatment permanently according to protocol (i.e. completed treatment with or without temporary treatment interruption)
- Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial
- Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. WOCBP taking oral contraceptives (OCs) also have to ensure the use of one barrier method during sexual intercourse with their partner, e.g., condom to account for the risk of potentially reduced efficacy of the OCs in the event of severe vomiting and diarrhoea. For France, fertile males must be ready and able to use acceptable methods of birth control
-
Any disease that may put the patient at risk when participating in this trial at investigator's discretion.
-
Patient exhibits suicidality, in the clinical judgment of the investigator or according to the following criteria at Visit 1:
- any suicidal behaviour (i.e. actual attempt, interrupted attempt, aborted attempt, or preparatory acts or behaviour)
- any suicidal ideation of type 4 or 5 in the Columbia-Suicide Severity Rating Scale (C-SSRS) (i.e. active suicidal thought with intent but without specific plan, or active suicidal thought with plan and intent)
-
Patients with clinically relevant severe depression at investigator's discretion or a Hospital Anxiety and Depression Scale (HADS) subscore >14 at Visit 1.
-
An occurrence of malignant neoplasm other than appropriately treated basal cell carcinoma or in situ squamous cell carcinoma of the skin or in situ carcinoma of uterine cervix at Visit 1.
-
Patient will undergo lung transplantation, with an assigned date of surgery.
-
Patients with a Body Mass index (BMI) <18.5 kg/m² that experienced an additional, unexplained and clinically significant (>10%) weight loss during the parent trial
-
At Visit 1, patients with ongoing Adverse Event of Special Interest (AESI), except for latent tuberculosis (suspected vasculitis, Drug Induced Liver Injury (DILI), severe infections) that led to temporary treatment interruption in the parent trial
-
Patients who must or wish to take restricted medications or any drug considered likely to interfere with the safe conduct of the trial.
Further exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description BI 1015550 treatment group BI 1015550 -
- Primary Outcome Measures
Name Time Method Occurrence of any adverse event over the course of the extension trial (yes/no) Up to 99 weeks and 3 days
- Secondary Outcome Measures
Name Time Method Time to first acute Idiopathic Pulmonary Fibrosis/Progressive Pulmonary Fibrosis (IPF/PPF) exacerbation, first hospitalisation for respiratory cause, or death (whichever occurs first) over the duration of the trial Up to 98 weeks Time to relative decline in Forced vital capacity (FVC) % predicted of >10% from baseline or death over the duration of the trial Up to 98 weeks Time to first acute Idiopathic Pulmonary Fibrosis/Progressive Pulmonary Fibrosis (IPF/PPF) exacerbation or death over the duration of the trial Up to 98 weeks Time to hospitalisation for respiratory cause or death over the duration of the trial Up to 98 weeks Absolute change from baseline in Forced vital capacity (FVC) (mL) over time Up to 98 weeks Absolute change from baseline in % predicted in Forced vital capacity (FVC) over time Up to 98 weeks Time to absolute decline in FVC % predicted of >10% from baseline over the duration of the trial Up to 98 weeks Time to absolute decline in Forced vital capacity (FVC) % predicted of >10% from baseline or death over the duration of the trial Up to 98 weeks
Trial Locations
- Locations (374)
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
University of Southern California
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
University of California Los Angeles
🇺🇸Los Angeles, California, United States
University of California Davis
🇺🇸Sacramento, California, United States
National Jewish Health
🇺🇸Denver, Colorado, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Christiana Hospital
🇺🇸Newark, Delaware, United States
Georgetown University
🇺🇸Washington, District of Columbia, United States
St. Francis Medical Institute
🇺🇸Clearwater, Florida, United States
University of Florida
🇺🇸Gainesville, Florida, United States
Clinical Research Specialists LLC
🇺🇸Kissimmee, Florida, United States
Advanced Pulmonary Research Institute
🇺🇸Loxahatchee Groves, Florida, United States
Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead
🇺🇸Atlanta, Georgia, United States
The Emory Clinic
🇺🇸Atlanta, Georgia, United States
Northshore University Health System
🇺🇸Evanston, Illinois, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Tulane Medical Center
🇺🇸New Orleans, Louisiana, United States
Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
St. Elizabeth's Medical Center
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
Corewell Health William Beaumont University Hospital
🇺🇸Royal Oak, Michigan, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic, Rochester
🇺🇸Rochester, Minnesota, United States
The Lung Research Center, LLC
🇺🇸Chesterfield, Missouri, United States
Creighton University
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Renown Regional Medical Center
🇺🇸Reno, Nevada, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Northern Westchester Hospital
🇺🇸Mount Kisco, New York, United States
Columbia University Medical Center-New York Presbyterian Hospital
🇺🇸New York, New York, United States
NewYork-Presbyterian/Weill Cornell Medical Center
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Southeastern Research Center-Winston Salem-69289
🇺🇸Winston-Salem, North Carolina, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center
🇺🇸Columbus, Ohio, United States
The Oregon Clinic
🇺🇸Portland, Oregon, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States
Temple University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Infinity Medical Research, Inc.
🇺🇸East Providence, Rhode Island, United States
Lowcountry Lung and Critical Care
🇺🇸Charleston, South Carolina, United States
Clinical Trials Center of Middle Tennessee, LLC
🇺🇸Franklin, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
UT Health San Antonio
🇺🇸San Antonio, Texas, United States
Intermountain Medical Center-Murray-69497
🇺🇸Murray, Utah, United States
University of Utah Health Sciences Center
🇺🇸Salt Lake City, Utah, United States
University of Vermont
🇺🇸Burlington, Vermont, United States
Inova Fairfax Hospital
🇺🇸Falls Church, Virginia, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553
🇦🇷C.a.b.a, Argentina
CEDIC - Centro de Investigacion Clinica
🇦🇷Caba, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Caba, Argentina
Consultorios Médicos del Buen Ayre
🇦🇷Capital Federal, Argentina
CEMER-Centro Medico De Enfermedades Respiratorias
🇦🇷Florida, Argentina
Instituto Ave Pulmo
🇦🇷Mar del Plata, Argentina
INSARES
🇦🇷Mendoza, Argentina
Centro Respiratorio de Quilmes
🇦🇷Quilmes, Argentina
Instituto Médico de la Fundación Estudios Clínicos
🇦🇷Rosario, Argentina
Canberra Hospital
🇦🇺Garran, Australian Capital Territory, Australia
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Lung Research Queensland
🇦🇺Chermside, Queensland, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Austin Hospital
🇦🇺Heidelberg, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
Trialswest
🇦🇺Spearwood, Western Australia, Australia
Macquarie University
🇦🇺Macquarie Park, Australia
Krems University Hospital
🇦🇹Krems, Austria
LKH Salzburg University Hospital
🇦🇹Salzburg, Austria
AKH - Medical University of Vienna
🇦🇹Vienna, Austria
Clinic Floridsdorf
🇦🇹Vienna, Austria
Klinikum Wels - Grieskirchen GmbH
🇦🇹Wels, Austria
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim
🇧🇪Antwerpen, Belgium
ULB Hopital Erasme
🇧🇪Bruxelles, Belgium
Brussels - UNIV Saint-Luc
🇧🇪Bruxelles, Belgium
UNIV UZ Gent
🇧🇪Gent, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
Centre Hospitalier Universitaire de Liège
🇧🇪Liège, Belgium
Yvoir - UNIV UCL de Mont-Godinne
🇧🇪Yvoir, Belgium
Serviços Medicos Respirar Sul Fluminense
🇧🇷Barra Mansa, Brazil
Hospital das Clinicas da Universidade Federal HC-UFMG
🇧🇷Belo Horizonte,Minas Gerais, Brazil
Edumed - Educacao e Saude SA
🇧🇷Curitiba, Brazil
CLARE - Clinica de Pneumologia
🇧🇷Goiania, Brazil
Hospital Nossa Senhora da Conceição
🇧🇷Porto Alegre - RS, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
🇧🇷São Bernardo do Campo, Brazil
Hospital das Clinicas da FMUSP
🇧🇷São Paulo, Brazil
University of Alberta Hospital (University of Alberta)
🇨🇦Edmonton, Alberta, Canada
Kelowna Respirology & Allergy Research
🇨🇦Kelowna, British Columbia, Canada
St. Paul's Hospital (Vancouver)
🇨🇦Vancouver, British Columbia, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Dr. Georges-L.-Dumont University Hospital Centre
🇨🇦Moncton, New Brunswick, Canada
QEII Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada
St. Joseph's Healthcare Hamilton
🇨🇦Hamilton, Ontario, Canada
Dr. Syed Anees Medicine Professional Corporation
🇨🇦Windsor, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
🇨🇦Montreal, Quebec, Canada
McGill University Health Centre (MUHC)
🇨🇦Montreal, Quebec, Canada
CIC Mauricie Inc.
🇨🇦Trois-Rivieres, Quebec, Canada
Royal University Hospital (Saskatoon)
🇨🇦Saskatoon, Saskatchewan, Canada
IUCPQ (Laval University)
🇨🇦Quebec, Canada
Instituto Nacional del Tórax
🇨🇱Providencia, Santiago De Chile, Chile
Centro de Investigación del Maule
🇨🇱Talca, Chile
Beijing Chao-Yang Hospital
🇨🇳Beijing, China
China-Japan Friendship Hospital
🇨🇳Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
The Second Xiangya Hospital Of Central South University
🇨🇳Changsha, China
West China Hospital
🇨🇳Chengdu, China
People's Hospital of Sichuan Province
🇨🇳Chengdu, China
First Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, China
NanFang Hosptial
🇨🇳Guangzhou, China
Hangzhou First People's Hospital
🇨🇳Hangzhou, China
The Second Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Zhejiang Hospital
🇨🇳Hangzhou, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
🇨🇳Hangzhou, China
Anhui Provincial Hospital
🇨🇳Hefei, China
The Affiliated Hospital of Inner Mongolia Medical University
🇨🇳Hohhot, China
The First hospital of Jiaxing
🇨🇳Jiaxing, China
Jinhua Municipal Central Hospital
🇨🇳Jinhua, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Ningbo Medical Center Lihuili Hospital
🇨🇳Ningbo, China
The First Affiliated Hospital of Ningbo University
🇨🇳Ningbo, China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, China
Shanghai Chest Hospital
🇨🇳Shanghai, China
Zhongshan Hospital Affiliated to Fudan University
🇨🇳Shanghai, China
Huadong Hospital affiliated to Fudan University
🇨🇳Shanghai, China
China Shenyang Chest Hospital
🇨🇳Shenyang, China
Shenzhen People's Hospital
🇨🇳Shenzhen, China
The University of Hong Kong-Shenzhen Hospital
🇨🇳Shenzhen, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
The First Affiliated Hospital of Wenzhou Med College
🇨🇳Wenzhou, China
Wuhan Union Hospital
🇨🇳Wuhan, China
Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T
🇨🇳Wuhan, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
Wuxi People's Hospital
🇨🇳Wuxi, China
Second Affiliated Hospital of Xi'an JiaoTong University
🇨🇳Xi'an, China
Affiliated Hospital, Xuzhou Medical college
🇨🇳Xuzhou, China
Yichang NO.1 People's Hospital
🇨🇳Yichang, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, China
University hospital center Zagreb
🇭🇷Zagreb, Croatia
University Hospital Dubrava
🇭🇷Zagreb, Croatia
Solmed Polyclinic
🇭🇷Zagreb, Croatia
Thomayer University Hospital
🇨🇿Praha 4, Czechia
Gentofte Hospital
🇩🇰Hellerup, Denmark
Odense University Hospital
🇩🇰Odense C, Denmark
North Estonia Medical Centre Foundation, Tallinn
🇪🇪Tallinn, Estonia
HYKS Keuhkosairauksien tutkimusyksikkö
🇫🇮Helsinki, Finland
Oulun yliopistollinen keskussairaala
🇫🇮Oulu, Finland
Tampere University Hospital
🇫🇮Tampere, Finland
TYKS
🇫🇮Turku, Finland
HOP d'Angers
🇫🇷Angers, France
HOP Avicenne
🇫🇷Bobigny, France
HOP de la Cavale Blanche
🇫🇷Brest, France
HOP Louis Pradel
🇫🇷Bron, France
HOP CHU Caen
🇫🇷Caen, France
HOP François Mitterrand
🇫🇷Dijon, France
HOP Michallon
🇫🇷La Tronche, France
HOP Bicêtre
🇫🇷Le Kremlin-Bicêtre, France
INS Coeur Poumon
🇫🇷Lille, France
HOP Nord
🇫🇷Marseille, France
HOP Nord Laennec
🇫🇷Nantes, France
HOP Pasteur
🇫🇷Nice, France
HOP Paris Saint-Joseph
🇫🇷Paris, France
HOP Européen G. Pompidou
🇫🇷Paris, France
HOP Bichat
🇫🇷Paris, France
HOP Haut-Lévêque
🇫🇷Pessac, France
HOP Robert Debré
🇫🇷Reims, France
HOP Pontchaillou
🇫🇷Rennes, France
HOP Charles Nicolle
🇫🇷Rouen, France
HOP Foch
🇫🇷Suresnes, France
HOP Larrey
🇫🇷Toulouse, France
National Center for Tuberculosis and Lung Diseases, Tbilisi
🇬🇪Tbilisi, Georgia
LLC Diacor
🇬🇪Tbilisi, Georgia
Velocity Clinical Research Germany GmbH-Ahrensburg-69816
🇩🇪Ahrensburg, Germany
CIMS Studienzentrum Bamberg GmbH
🇩🇪Bamberg, Germany
Vivantes Netzwerk für Gesundheit GmbH
🇩🇪Berlin, Germany
Universitätsklinikum Bonn AöR
🇩🇪Bonn, Germany
Fachkrankenhaus Coswig GmbH
🇩🇪Coswig, Germany
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
🇩🇪Essen, Germany
Universitätsklinikum Hamburg, Eppendorf
🇩🇪Hamburg, Germany
Klinikum Region Hannover GmbH
🇩🇪Hannover, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Lungenklinik Hemer
🇩🇪Hemer, Germany
Lungenfachklinik Immenhausen
🇩🇪Immenhausen, Germany
Klinikum Konstanz
🇩🇪Konstanz, Germany
Klinikum der Universität München AÖR
🇩🇪München, Germany
Klinikum Nürnberg
🇩🇪Nürnberg, Germany
Krankenhaus Bethanien gGmbH
🇩🇪Solingen, Germany
Helios Hanseklinikum Stralsund
🇩🇪Stralsund, Germany
Robert Bosch Gesellschaft für medizinische Forschung mbH
🇩🇪Stuttgart, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Germany
Hospital of Heraklion (PAGNI)
🇬🇷Heraclion, Greece
Univ. Gen. Hosp. of Ioannina
🇬🇷Ioannina, Greece
Univ. Gen. Hosp. of Patras
🇬🇷Patras, Greece
General Hospital of Thessaloniki "Hippokrateio"
🇬🇷Thessaloniki, Greece
Semmelweis University
🇭🇺Budapest, Hungary
Koranyi National Institute For Pulmonolgy
🇭🇺Budapest, Hungary
University of Debrecen Clinical Centre
🇭🇺Debrecen, Hungary
Bhatia Hospital
🇮🇳Mumbai, India
P.D. Hinduja National Hospital
🇮🇳Mumbai, India
Connolly Hospital Blanchardstown
🇮🇪Dublin 15, Ireland
Shamir Medical Center (Assaf Harofeh)
🇮🇱Beer Yaakov, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center, Jerusalem 91031
🇮🇱Jerusalem, Israel
Sourasky Medical Center
🇮🇱Tel Aviv, Israel
ASST degli Spedali Civili di Brescia
🇮🇹Brescia, Italy
A.O.U. Policlinico Vittorio Emanuele
🇮🇹Catania, Italy
A. O. Universitaria Careggi
🇮🇹Firenze, Italy
Ospedale Colonnello D Avanzo
🇮🇹Foggia, Italy
Ospedale G.B. Morgagni
🇮🇹Forli', Italy
Ospedale San Paolo-MILANO-18793
🇮🇹Milano, Italy
Ospedale Classificato San Giuseppe
🇮🇹Milano, Italy
Azienda Ospedaliera Policlinico di Modena
🇮🇹Modena, Italy
A.O. San Gerardo di Monza
🇮🇹Monza, Italy
Azienda Ospedaliera Universitaria di Padova
🇮🇹Padova, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS
🇮🇹Roma, Italy
A.O.U. Senese Policlinico Santa Maria alle Scotte
🇮🇹Siena, Italy
Ospedali Riuniti di Ancona
🇮🇹Torrette Di Ancona (Ancona), Italy
Tosei General Hospital
🇯🇵Aichi, Seto, Japan
Chiba University Hospital
🇯🇵Chiba, Chiba, Japan
University of Fukui Hospital
🇯🇵Fukui, Yoshida-gun, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Fukuoka, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Fukuoka, Japan
Aso Co.,Ltd Iizuka Hospital
🇯🇵Fukuoka, Iizuka, Japan
Hospital of the University of Occupational and Environmental Health
🇯🇵Fukuoka, Kitakyushu, Japan
Kurume University Hospital
🇯🇵Fukuoka, Kurume, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima, Fukushima, Japan
Tsuboi Hospital
🇯🇵Fukushima, Koriyama, Japan
Hiroshima Prefectural Hospital
🇯🇵Hiroshima, Hiroshima, Japan
Sapporo Medical University Hospital
🇯🇵Hokkaido, Sapporo, Japan
Hokkaido University Hospital
🇯🇵Hokkaido, Sapporo, Japan
National Hospital Organization Himeji Medical Center
🇯🇵Hyogo, Himeji, Japan
Kobe City Medical Center General Hospital
🇯🇵Hyogo, Kobe, Japan
Kobe City Hospital Organization Kobe City Medical Center West Hospital
🇯🇵Hyogo, Kobe, Japan
Kagawa University Hospital
🇯🇵Kagawa, Kita-gun, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Kanagawa, Yokohama, Japan
Saiseikai Kumamoto Hospital
🇯🇵Kumamoto, Kumamoto, Japan
Tohoku University Hospital
🇯🇵Miyagi, Sendai, Japan
Nagasaki University Hospital
🇯🇵Nagasaki, Nagasaki, Japan
Kindai University Hospital
🇯🇵Osaka, Osakasayama, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center
🇯🇵Osaka, Sakai, Japan
Osaka Medical and Pharmaceutical University Hospital
🇯🇵Osaka, Takatsuki, Japan
Saitama Red Cross Hospital
🇯🇵Saitama, Saitama, Japan
Shimane University Hospital
🇯🇵Shimane, Izumo, Japan
Hamamatsu University Hospital
🇯🇵Shizuoka, Hamamatsu, Japan
Jichi Medical University Hospital
🇯🇵Tochigi, Shimotsuke, Japan
Tokushima University Hospital
🇯🇵Tokushima, Tokushima, Japan
Juntendo University Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Nippon Medical School Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Toranomon Hospital
🇯🇵Tokyo, Minato-ku, Japan
Kyorin University Hospital
🇯🇵Tokyo, Mitaka, Japan
Toho University Omori Medical Center
🇯🇵Tokyo, Ota-ku, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Shinjuku-ku, Japan
Keio University Hospital
🇯🇵Tokyo, Shinjuku-ku, Japan
National Center for Global Health and Medicine
🇯🇵Tokyo, Shinjuku-ku, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Wakayama, Japan
The Catholic University of Korea, Bucheon St.Mary's Hospital
🇰🇷Bucheon, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Soonchunhyang University Hospital Seoul
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital Pulau Pinang-Pulau Pinang-21953
🇲🇾George Town, Malaysia
Hospital Sultan Idris Shah Serdang
🇲🇾Kajang, Malaysia
Institut Perubatan Respiratori
🇲🇾Kuala Lumpur, Malaysia
Sarawak General Hospital
🇲🇾Kuching, Malaysia
Centro de Investigacion Integral MEDIVEST S.C
🇲🇽Chihuahua, Mexico
Centro Respiratorio de Mexico
🇲🇽Ciudad de Mexico, Mexico
Soltmed Smo
🇲🇽Ciudad de Mexico, Mexico
CREPID Aire y Salud Integral
🇲🇽Coyoacan, Mexico
Centro de Investigacion Farmacologica del Bajío, S.C.
🇲🇽Guanajuato, Mexico
Centro de Prevención y Rehabilitación de Enfermedades Pulmon
🇲🇽Monterrey, Mexico
Oaxaca Site Management Organization, S.C.
🇲🇽Oaxaca, Mexico
Zuyderland Medisch Centrum
🇳🇱HEERLENHeerlen, Netherlands
Leids Universitair Medisch Centrum (LUMC)
🇳🇱Leiden, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
Erasmus Medisch Centrum-ROTTERDAM-50697
🇳🇱Rotterdam, Netherlands
Waikato Hospital
🇳🇿Hamilton, New Zealand
Greenlane Clinical Centre
🇳🇿One Tree Hill, Auckland, New Zealand
Tauranga Hospital
🇳🇿Tauranga South, New Zealand
Haukeland Universitetssykehus
🇳🇴Bergen, Norway
Akershus Universitetssykehus HF
🇳🇴Nordbyhagen, Norway
Oslo Universitetssykehus HF, Rikshospitalet
🇳🇴Oslo, Norway
University Clinical Center, Gdansk
🇵🇱Gdansk, Poland
Leszek Giec Upper-Silesian Med.Cent.Silesian Med.Univ.
🇵🇱Katowice, Poland
Alergopneuma Medical Center
🇵🇱Swidnik, Poland
Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa
🇵🇱Warsaw, Poland
University Clinical Center of the Medical University of Warsaw
🇵🇱Warsaw, Poland
ULS Braga
🇵🇹Braga, Portugal
ULS de Coimbra, E.P.E.
🇵🇹Coimbra, Portugal
ULS de São José, E.P.E.
🇵🇹Lisboa, Portugal
USLM, EPE - Hospital Pedro Hispano
🇵🇹Matosinhos, Portugal
ULS de Gaia/Espinho, EPE
🇵🇹Vila Nova de Gaia, Portugal
Allianze Pulmonary Research LLC
🇵🇷Guaynabo, Puerto Rico
King Abdullah International Medical Research Center
🇸🇦Riyadh, Saudi Arabia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
University Clinical Center Nis
🇷🇸Nis, Serbia
Institute for Pulmonary Diseases of Vojvodina
🇷🇸Sremska Kamenica, Serbia
Singapore General Hospital
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Hospital Golnik - Univ. Clinic of Pulmonary and Allergic Diseases
🇸🇮Golnik, Slovenia
Enhancing Care Foundation NPC
🇿🇦Mount Edgecombe, South Africa
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Spain
Hospital de Basurto
🇪🇸Bilbao, Spain
Hospital Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Hospital de Galdakao
🇪🇸Galdakao, Spain
Hospital Universitario Virgen de las Nieves
🇪🇸Granada, Spain
Hospital de Bellvitge
🇪🇸L'Hospitalet de Llobregat, Spain
Hospital La Princesa
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Ramón y Cajal
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Central de Asturias
🇪🇸Oviedo, Spain
Hospital Son Espases
🇪🇸Palma de Mallorca, Spain
Hospital Quirónsalud Madrid
🇪🇸Pozuelo de Alarcón, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital Clínico de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Nuestra Señora de Valme
🇪🇸Sevilla, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Universitetssjukhuset, Linköping
🇸🇪Linköping, Sweden
Akademiska sjukhuset
🇸🇪Uppsala, Sweden
University Hospital Basel
🇨🇭Basel, Switzerland
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
NCKUH
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Siriraj Hospital
🇹🇭Bangkok Noi, Thailand
Srinagarind Hospital
🇹🇭Khon Kaen, Thailand
Maharat Nakhonchiangmai Hospital
🇹🇭Muang, Thailand
Ramathibodi Hospital
🇹🇭Ratchatewi, Thailand
Songklanagarind Hospital
🇹🇭Songkhla, Thailand
Gulhane Training and Research Hospital
🇹🇷Ankara, Turkey
Ankara Universitesi Tip Fakultesi
🇹🇷Ankara, Turkey
Akdeniz Universitesi Tip Fakultesi -ANTALYA-33606
🇹🇷Antalya, Turkey
Istanbul Universitesi Istanbul Tip Fakultesi
🇹🇷Istanbul, Turkey
Gazi Universitesi Tip Fakultesi
🇹🇷Yenimahalle/ANKARA, Turkey
Aberdeen Royal Infirmary
🇬🇧Aberdeen, United Kingdom
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Southmead Hospital
🇬🇧Bristol, United Kingdom
Royal Infirmary of Edinburgh
🇬🇧Edinburgh, United Kingdom
Royal Devon and Exeter Hospital, Wonford
🇬🇧Exeter, United Kingdom
Royal Lancaster Infirmary
🇬🇧Lancaster, United Kingdom
St James's University Hospital
🇬🇧Leeds, United Kingdom
Altnagelvin Area Hospital
🇬🇧Londonderry, United Kingdom
Guy's Hospital
🇬🇧London, United Kingdom
Royal Brompton Hospital
🇬🇧London, United Kingdom
Wythenshawe Hospital
🇬🇧Manchester, United Kingdom
Churchill Hospital
🇬🇧Oxford, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom