Diagnostics of metal allergy associated with oral exposure

Conditions: tandheelkundige slijmvlies aandoeningen
Metal allergy
10001708
10014982

Registration Number: NL-OMON30428

Lead Sponsor: niversiteit van Amsterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

Patients (>18 year) where the anamnesis gives rise to a suspicion of a metal allergy based on an oral exposure and where intra-oral inspection showed one of the following symptoms:
1) not plaque related mucosa deviation (e.g. gingivitis, periodontitis),
2) Lichenoid reaction,
3) Lingua geographica,
4) Local erosion,
5) Edema,
6) Erythema.

Exclusion Criteria

Patients/volunteers where the anamnesis showed malignancies and/or systemic diseases, or other disorders that hinder the execution of in vivo or in vitro allergy testing. ;Patients/volunteers who are pregnant.;The use of drugs that interferes with in vivo and/or in vitro allergic diagnostic tests.;Patients not willing to undergo the general diagnostic examination as normally offered by the department of Dermato-Allergy (VUmc) or the department of Oral Diagnostics (ACTA).;Patients of the negative control group were not positive patch tested before and should not have a history of eczema.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determination of correlation coefficients between test results of four selected<br /><br>tests mutually as well as in relation with the diagnostic image of metal<br /><br>allergiy linked to an oral exposure to dental alloys.</p><br>

Secondary Outcome Measures