Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 1,800
- Primary Endpoint
- Cognitive Function driving Behaviour
Study Overview
Brief Summary
We will examine how stimulation of specific brain areas with transcranial magnetic stimulation (TMS) or transcranial electric stimulation (tES) changes specific aspects of behavior and brain activity, in order to test hypotheses about brain behavior relationships (basic research).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age)
- •right-handedness and/or one specific gender (male or female) can be inclusion criteria to reduce variation in the data.
Exclusion Criteria
- •inability to understand the instructions and insufficient knowledge of the project language
- •Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding)
- •One or more epileptic fits in the participant or a first-degree relative
- •Vascular, traumatic, tumoral, infectious, or metabolic brain damage
- •Use of medication that significantly alters cortical excitability
- •Acute sleep deprivation or withdrawal from alcohol
- •pregnancy
- •to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.
Outcomes
Primary Outcomes
Cognitive Function driving Behaviour
Time Frame: 0-60 minutes after stimulation
Parameter of Model describing cognitive function governing behaviour
Accuracy of Behaviour
Time Frame: 0-60 minutes after stimulation
Accuracy in percent correct
Brain activity
Time Frame: 0-60 minutes after stimulation
BOLD contrast in fMRI data
Speed of Behaviour
Time Frame: 0-60 minutes after stimulation
Reaction time in miliseconds
Secondary Outcomes
No secondary outcomes reported
Investigators
Christian Ruff
Prof. Dr.
University of Zurich