Mechanism of Action of Transcranial Magnetic Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Changes in Functional Connectivity of Key Nodes in Depression
研究概览
简要总结
This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.
详细描述
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar depression receiving TMS. Patients will be scanned before and after a full course of TMS and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of TMS at the circuit level (2) to study the use of fcMRI as a state biomarker for depression (3) to study the use of fcMRI as a predictor of response for depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males and females between the ages of 18-80
- •DSM-IV diagnosis of Depressive Episode
- •Patients requiring TMS treatment as part of their psychiatric care
排除标准
- •Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia.
- •Substance use disorder (abuse or dependence) with active use within the last 3 months
- •Severe or unstable medical illness.
- •MRI contraindications as determined by MGH department of radiology.
研究组 & 干预措施
Unipolar Depression
Patients diagnosed with unipolar depression.
干预措施: Transcranial Magnetic Stimulation (Device)
结局指标
主要结局
Changes in Functional Connectivity of Key Nodes in Depression
时间窗: Through Treatment Completion, Average of 6 Weeks
Measured by Magnetic Resonance Imaging
次要结局
未报告次要终点
研究者
Joan A Camprodon, MD MPH PhD
Chief of Division of Neuropsychiatry, Director of TMS Clinic, Director of Lab for Neuropsychiatry and Neuromodulation
Massachusetts General Hospital