Mechanism of Action of Transcranial Magnetic Stimulation
- Conditions
- DepressionMajor Depressive Disorder
- Registration Number
- NCT04278521
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.
- Detailed Description
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar depression receiving TMS. Patients will be scanned before and after a full course of TMS and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of TMS at the circuit level (2) to study the use of fcMRI as a state biomarker for depression (3) to study the use of fcMRI as a predictor of response for depression.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 54
- Males and females between the ages of 18-80
- DSM-IV diagnosis of Depressive Episode
- Patients requiring TMS treatment as part of their psychiatric care
- Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia.
- Substance use disorder (abuse or dependence) with active use within the last 3 months
- Severe or unstable medical illness.
- MRI contraindications as determined by MGH department of radiology.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Changes in Functional Connectivity of Key Nodes in Depression Through Treatment Completion, Average of 6 Weeks Measured by Magnetic Resonance Imaging
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital🇺🇸Boston, Massachusetts, United States