NCT01350427CompletedNot Applicable
Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Sao Paulo
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Protein synthesis
Study Overview
Brief Summary
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Sedentaries
- •Must be able to exercise
- •Must be able to swallow tablets
Exclusion Criteria
- •Use of nutritional supplements
- •Use of anti-inflammatory drugs
Arms & Interventions
Leucine
Experimental
Intervention: Leucine supplementation (Dietary Supplement)
BCAA
Experimental
Intervention: BCAA supplementation (Dietary Supplement)
Placebo
Placebo Comparator
Intervention: Alanine supplementation (Dietary Supplement)
Outcomes
Primary Outcomes
Protein synthesis
Time Frame: 1 hour
Phosphorylation of proteins involved in protein synthesis
Protein degradation
Time Frame: 1 hour
Expression of protein involved in proteolytic pathway
Inflammation
Time Frame: 1 hour
Expression of systemic and muscular cytokines
Secondary Outcomes
No secondary outcomes reported
Investigators
Humberto Nicastro
PhD
University of Sao Paulo
Study Sites (1)
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