Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women
试验速览
- 阶段
- 不适用
- 入组人数
- 70
- 主要终点
- Wrinkles
研究概览
简要总结
Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin.
We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •50 - 70 years old
- •Postmenopausal
- •Fitzpatrick skin type I, II, or III
- •BMI 18.5 - 35
- •Must be willing to comply with all protocol requirements
- •Must be willing to have flash photo facial images taken with the imaging systems
排除标准
- •Allergy to mangos
- •Vegans/vegetarians
- •Adults unable to consent
结局指标
主要结局
Wrinkles
时间窗: week 20
Wrinkle score measured by Facial Image Analysis System
次要结局
- Facial Elasticity(week 20)
- Gut microbiome(week 20)
- Facial Hydration(week 20)
- Facial Redness(week 20)