Coronary CT Angiography to Predict Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN (CTA -VISION) Study

Completed

• Conditions: Cardiovascular Disease
• Interventions: Other: Coronary CT Angiogram

• Registration Number: NCT01635309
• Lead Sponsor: Canadian Institutes of Health Research (CIHR)

Brief Summary

Worldwide 200 million adults annually undergo major noncardiac surgery and 5 million of these patients will suffer a major vascular complication. Despite the magnitude of this problem our capacity to predict these events is limited. Although perioperative myocardial infarction (MI) is the most common major perioperative cardiac complication, little is known about its pathophysiology. Coronary computed tomography angiography (CTA) is a potential non-invasive method for the detection of coronary artery disease and cardiac risk stratification in the non-operative setting; however, the value of this test to enhance risk prediction among patients scheduled for noncardiac surgery is unknown. This study is an international prospective cohort study to determine among patients with, or at risk of, atherosclerotic disease who are undergoing noncardiac surgery: 1) if preoperative coronary CTA has additional predictive value for the occurrence of major perioperative cardiac events and 2) the underlying coronary anatomy associated with perioperative MIs.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2012-07-04
• Study First Submitted QC: 2012-07-06
• Study First Posted: 2012-07-09
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-27
• Last Update Posted: 2015-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 987

Inclusion Criteria

• age >=45 years

• undergoing non cardiac surgery requiring an overnight stay and general or regional anaesthetic

• at least one of:

  1. Coronary Artery Disease (CAD)
  2. Peripheral Vascular Disease (PVD)
  3. History of Stroke
  4. History of Congestive Heart Failure (CHF)
  5. Combination of at least 3 of:

• age >= 70 years

• history of treatment for hypertension

• history of treatment for dyslipidemia

• smoking in last 2 years

• diabetic and currently taking insulin or oral diabetic drugs

• history of Transient Ischemic Attack (TIA)

Exclusion Criteria

• contraindications to CTA

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-cardiac surgical patients	Coronary CT Angiogram	\>= 45 years old, undergoing non-cardiac surgery requiring regional or general anaesthetic and an overnight stay with cardiac risk factors

Primary Outcome Measures

Name	Time	Method
Perioperative MI	30-days post-operative

Secondary Outcome Measures

Name	Time	Method
Perioperative Cardiovascular Event	30-days post-operative

Trial Locations

Locations (1)

Juravinski Hospital; 🇨🇦 Hamilton, Ontario, Canada