Research of Revascularization in Immature Teeth With Periapical Periodontitis

Not Applicable

• Conditions: Periapical Periodontitis
• Interventions: Procedure: revascularization; Procedure: apexification

• Registration Number: NCT01799187
• Lead Sponsor: Junqi Ling

Brief Summary

Revascularization is an alternative new treatment of immature permanent teeth with necrotic pulp nowadays while apexification is the traditional therapy. The investigators suppose that revascularization is superior to apexification at developing the root of immature permanent teeth and reducing the risk of root fracture,and the research is designed.

Detailed Description

The investigators design to collect a group of patients presenting immature permanent teeth with periapical periodontitis in certain criterion. The investigators will divide the patients into two groups randomly. One group will get treated with revascularization while the other with apexification. The investigators want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of revascularization.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2013-02-24
• Study First Submitted QC: 2013-02-25
• Study First Posted: 2013-02-26
• Status Verified: 2014-07
• Last Update Submitted: 2014-07-19
• Last Update Posted: 2014-07-22
• Primary Completion: 2015-07
• Study Completion: 2021-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 190

Inclusion Criteria

• clinical diagnosis of periapical periodontitis
• must be immature permanent teeth
• must be local Guangzhou

Exclusion Criteria

• blood disease
• residual root that is advised to extract
• serious periodontitis
• women in pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
revascularization	revascularization	revascularization is is an alternative new treatment of immature permanent teeth with necrotic pulp. The use of triple antibiotic paste is followed by Induction of bleeding from the apical root during this intervention.
apexification	apexification	apexification is a traditional therapy of immature permanent teeth with necrotic pulp.calcium hydroxide is served as medication to induce the developing of root .

Primary Outcome Measures

Name	Time	Method
Evidence of lesion healing confirmed by cone beam computed tomography	one year

Trial Locations

Locations (1)

Guanghua hospital of stomotology,Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China